TY - JOUR
TI - Dose verification in clinical imrt prostate incidents
AU - Sandilos, P.
AU - Angelopoulos, A.
AU - Baras, P.
AU - Dardoufas, K.
AU - Karaiskos, P.
AU - Kipouros, P.
AU - Kozicki, M.
AU - Rosiak, J.M.
AU - Sakelliou, L.
AU - Seimenis, I.
AU - Vlahos, L.
JO - International Journal of Radiation, Oncology, Biology, Physics
PY - 2004
VL - 59
TODO - 5
SP - 1540-1547
PB - 
SN - 0360-3016
TODO - 10.1016/j.ijrobp.2004.04.029
TODO - Intensity modulated radiation therapy (IMRT);  Polymer gels, Disease control;  Dosimetry;  Gels;  Ionization chambers;  Magnetic resonance imaging, Radiotherapy, polymer, article;  film dosimeter;  gel;  histogram;  human;  intensity modulated radiation therapy;  ionization chamber;  male;  mathematical computing;  measurement;  medical instrumentation;  nuclear magnetic resonance imaging;  priority journal;  prostate cancer;  radiation dose;  radiation dose distribution;  three dimensional imaging;  treatment planning;  validation process, Humans;  Male;  Phantoms, Imaging;  Radiometry;  Radiotherapy Dosage;  Radiotherapy Planning, Computer-Assisted;  Radiotherapy, Conformal
TODO - Purpose In view of the need for dose-validation procedures on each individual intensity-modulated radiation therapy (IMRT) plan, dose-verification measurements by film, by ionization chamber, and by polymer gel-MRI dosimetry were performed for a prostate-treatment plan configuration. Treatment planning system (TPS) calculations were evaluated against dose measurements. Methods and materials Intensity-modulated radiation therapy (IMRT) treatments were planned on a commercial TPS. Kodak EDR-2 films were used for the verification of two-dimensional (2D) dose distributions at 1 coronal and 5 axial planes in a water-equivalent phantom. Full three-dimensional (3D) dose distributions were measured by use of a novel polymer gel formulation and a 3D magnetic resonance imaging (MRI) readout technique. Calculations were compared against measurements by means of isocontour maps, γ-index maps (3% dose difference, 3-mm distance to agreement) and dose-volume histograms. Results A good agreement was found between film measurements and TPS predictions for points within the 60% isocontour, for all the examined plans (γ-index <1 for 96% of pixels). Three-dimensional dose distributions obtained with the polymer gel-MRI method were adequately matched with corresponding TPS calculations, for measurements in a gel phantom covering the planning-target volume (PTV). Conclusions Measured 2D and 3D dose distributions suggest that, for the investigated prostate IMRT plan configuration, TPS calculations provide clinically acceptable accuracy. © 2004 Elsevier Inc.
ER -