TY - JOUR
TI - The effect of antioxidant and anti-inflammatory capacity of diet on psoriasis and psoriatic arthritis phenotype: Nutrition as therapeutic tool?
AU - Katsimbri, P.
AU - Korakas, E.
AU - Kountouri, A.
AU - Ikonomidis, I.
AU - Tsougos, E.
AU - Vlachos, D.
AU - Papadavid, E.
AU - Raptis, A.
AU - Lambadiari, V.
JO - Free Radicals and Antioxidants
PY - 2021
VL - 10
TODO - 2
SP - 1-28
PB - MDPI
SN - 2231-2536
TODO - 10.3390/antiox10020157
TODO - null
TODO - Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system and may lead to the overproduction of pro-inflammatory cytokines. Fatty acids as macronutrients are key players for immunomodulation, with n-3 polyunsaturated fatty acids having the most beneficial effect, while polyphenols and carotenoids seem to be the most promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease with multifactorial etiology. Obesity is a major risk factor for psoriasis, which leads to worse clinical outcomes. Weight loss interventions and, generally, dietary regimens such as gluten-free and Mediterranean diet or supplement use may potentially improve psoriasis’ natural course and response to therapy. However, data about more sophisticated nutritional patterns, such as ketogenic, very low-carb or specific macro-and micro-nutrient substitution, are scarce. This review aims to present the effect of strictly structured dietary nutrients, that are known to affect glucose/lipid metabolism and insulin responses, on chronic inflammation and immunity, and to discuss the utility of nutritional regimens as possible therapeutic tools for psoriasis and psoriatic arthritis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ER -