TY - JOUR
TI - How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
AU - Thomakos, N.
AU - Dimopoulou, S.
AU - Sotiropoulou, M.
AU - Machairiotis, N.
AU - Pandraklakis, A.
AU - Haidopoulos, D.
AU - Liontos, M.
AU - Bamias, A.
AU - Rodolakis, A.
JO - Hormone Molecular Biology and Clinical Investigation
PY - 2021
VL - 42
TODO - 1
SP - 105-111
PB - De Gruyter Open Ltd
SN - 1868-1883, 1868-1891
TODO - 10.1515/hmbci-2020-0042
TODO - cisplatin;  estrogen receptor;  Ki 67 antigen;  protein p53;  vimentin, aged;  brachytherapy;  cancer chemotherapy;  cancer grading;  cancer patient;  cancer prognosis;  cancer recurrence;  cancer staging;  cancer surgery;  cancer survival;  clear cell carcinoma;  comparative study;  controlled study;  disease free survival;  endometrioid carcinoma;  endometrium carcinoma;  external beam radiotherapy;  female;  follow up;  histology;  histopathology;  human;  human tissue;  immunohistochemistry;  lymph node dissection;  lymph vessel;  major clinical study;  mixed cell culture;  omentectomy;  overall survival;  priority journal;  radical hysterectomy;  retrospective study;  Review;  salpingooophorectomy;  tumor volume;  uterus cancer;  adenocarcinoma;  adult;  antibody specificity;  disease exacerbation;  endometrium tumor;  Kaplan Meier method;  metastasis;  middle aged;  mortality;  pathology;  prognosis;  tumor invasion;  tumor recurrence;  very elderly, Adenocarcinoma, Clear Cell;  Adult;  Aged;  Aged, 80 and over;  Carcinoma, Endometrioid;  Disease Progression;  Endometrial Neoplasms;  Female;  Humans;  Kaplan-Meier Estimate;  Middle Aged;  Neoplasm Invasiveness;  Neoplasm Metastasis;  Neoplasm Recurrence, Local;  Organ Specificity;  Prognosis;  Retrospective Studies
TODO - The aim of this study is to evaluate and compare outcomes of patients with mixed and pure endometrial carcinomas (MEC). We reviewed data of patients with MEC, endometroid (EC), serous (SC), and clear cell (CC) carcinomas between 2002 and 2015. Overall survival (OS) and disease-free (DF) survival rates were evaluated, according to the percentage of histologic components. Clinicopathological variables and treatment strategies were assessed. Furthermore, χ2 tests were used to compare proportions and Kaplan–Meier curves to compare recurrence and survival. Sample consisted of 302 cases with mean age 66.3 years. Early-stage disease was recorded in EC compared with CC and SC. Adnexal involvement was more frequent in MEC compared with EC (p=0.043). Extra uterine metastasis was more frequent in the SC compared to the EC group, while lymphovascular space involvement was more frequent in the MEC and CC compared to the SC (p=0.001). EC had less omentum involvement compared to CC (p=0.035) and SC (p<0.001). Furthermore, cervical involvement was more frequent in CC compared to EC (p=0.011). Recurrence (p=0.265) and OS (p=0.533) were found to be similar in MEC compared with CC, SC, and EC. Moreover, recurrence and OS were similar between EC-CC and EC-SC. There were no differences in recurrence and survival in MEC with a type II component larger than 10% or 20% (p>0.05). © 2021 De Gruyter. All rights reserved.
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