TY - JOUR
TI - Impact of topoisomerases complex deregulation on head and neck carcinoma genomic instability
AU - Kyrodimos, E.
AU - Chrysovergis, A.
AU - Mastronikolis, N.
AU - Tsiambas, E.
AU - Ragos, V.
AU - Peschos, D.
AU - Spyropouloy, D.
AU - Pantos, P.
AU - Niotis, A.
AU - Papanikolaou, V.
JO - ANTICANCER RESEARCH
PY - 2021
VL - 41
TODO - 6
SP - 2773-2779
PB - International Institute of Anticancer Research
SN - 0250-1291
TODO - 10.21873/anticanres.15058
TODO - DNA topoisomerase;  DNA topoisomerase inhibitor;  DNA topoisomerase, cancer staging;  deregulation;  gene function;  gene structure;  genomic instability;  head and neck carcinoma;  human;  malignant transformation;  phenotype;  protein degradation;  protein function;  protein structure;  Review;  structure activity relation;  enzymology;  genetics;  head and neck tumor;  metabolism;  pathology, DNA Topoisomerases, Type I;  Genomic Instability;  Head and Neck Neoplasms;  Humans;  Squamous Cell Carcinoma of Head and Neck
TODO - Head and neck carcinoma (HNC) comprises a variety of pathological entities. Among them, squamous cell carcinoma (SCC) is histo-pathologically prominent. Specific malignancies, such as nasopharyngeal carcinoma (NPC) arise also from the same anatomical region. In all of them, genomic instability (GI) is implicated not only in the early stages of epithelial malignant transformation, but also in the aggressiveness of the corresponding phenotypes. Among the molecules that are frequently deregulated in solid malignancies including HNCs, topoisomerases (Topo) are of increased significance due to their involvement in DNA topological, structural, and functional stability. The main members are Topo I (20q11), Topo II alpha (17q21) and Topo IIb (3p24). In the current article, we describe the mechanisms of Topo I and Topo IIa deregulation leading to GI in a variety of HNCs. Furthermore, novel data regarding the corresponding targeted therapeutic strategies are presented. © 2021 International Institute of Anticancer Research. All rights reserved.
ER -