TY - JOUR
TI - MTHFR Polymorphisms in Girls with Anorexia Nervosa: Implications on Body Weight
AU - Augoulea, A.
AU - Armeni, E.
AU - Deligeoroglou, E.
AU - Paschou, S.A.
AU - Papadimitriou, G.
AU - Stergioti, E.
AU - Karountzos, V.
AU - Tsitsika, A.
AU - Panoulis, K.
AU - Economou, E.
AU - Lambrinoudaki, I.
JO - Endocrine Research
PY - 2021
VL - 46
TODO - 2
SP - 80-85
PB - Taylor and Francis Ltd.
SN - 0743-5800, 1532-4206
TODO - 10.1080/07435800.2021.1879845
TODO - 5 methyltetrahydrofolic acid;  blood clotting factor 13;  blood clotting factor 5;  blood clotting factor 5 Leiden;  DNA;  estradiol;  estrogen;  fibrinogen receptor;  methylenetetrahydrofolate reductase (NADPH2);  prothrombin;  methylenetetrahydrofolate reductase (NADPH2);  MTHFR protein, human, adolescent;  amenorrhea;  anorexia nervosa;  anthropometric parameters;  Article;  blood sampling;  body mass;  body weight;  body weight loss;  child;  clinical article;  controlled study;  cross-sectional study;  DNA polymorphism;  DSM-5;  electrochemiluminescence immunoassay;  female;  genetic association;  genetic polymorphism;  genotype;  hormone determination;  human;  menstruation;  pilot study;  polymerase chain reaction;  prevalence;  priority journal;  thrombosis;  anorexia nervosa;  body weight;  genetic polymorphism;  genetics;  pathophysiology;  physiology, Adolescent;  Anorexia Nervosa;  Body Weight;  Cross-Sectional Studies;  Female;  Humans;  Methylenetetrahydrofolate Reductase (NADPH2);  Pilot Projects;  Polymorphism, Genetic
TODO - The development of atypical vs typical anorexia nervosa (AN) might be explained by the genetic background. We assessed the link between the subtypes of AN and the genetic polymorphisms of the thrombotic panel and the methyltetrahydrofolate reductase (MTHFR) gene. This cross-sectional pilot study recruited 48 girls with AN and 10 age-matched control girls with normal menstruation. We recorded anthropometric parameters and obtained blood samples for genotyping and hormonal assessment. Classification of AN was performed according to the DSM-V criteria. Girls with AN had 2.66 times higher odds of carrying at least one genetic polymorphism from the MTHFR panel (C677T and A1298C) compared with girls without AN (OR = 2.660, p-value = 0.041; CI 95% 1.057–6.720). The presence of atypical vs typical AN was associated independently with the presence of any of the assessed MTHFR polymorphisms (C677T, OR = 4.929, 95% CI 1.076–22.579, p-value = 0.040; A1298C, OR = 0.097, 95% CI 0.011–0.866, p-value = 0.037) in age and estrogen adjusted models. The atypical presentation of AN is mainly linked with higher prevalence of the MTHFR C677T and lower prevalence of the A1298C polymorphism. © 2021 Taylor & Francis Group, LLC.
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