TY - JOUR
TI - The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents
AU - Mitsiogianni, M.
AU - Koutsidis, G.
AU - Mavroudis, N.
AU - Trafalis, D.T.
AU - Botaitis, S.
AU - Franco, R.
AU - Zoumpourlis, V.
AU - Amery, T.
AU - Galanis, A.
AU - Pappa, A.
AU - Panayiotidis, M.I.
JO - Free Radicals and Antioxidants
PY - 2019
VL - 8
TODO - 4
SP - null
PB - MDPI
SN - 2231-2536
TODO - 10.3390/antiox8040106
TODO - null
TODO - Many studies have shown evidence in support of the beneficial effects of hytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies. © 2019 by the authors.
ER -