TY - JOUR
TI - Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma
AU - Stanciu, A.E.
AU - Zamfir-Chiru-Anton, A.
AU - Stanciu, M.M.
AU - Stoian, A.P.
AU - Jinga, V.
AU - Nitipir, C.
AU - Bucur, A.
AU - Pituru, T.S.
AU - Arsene, A.L.
AU - Dragoi, C.M.
AU - Hainarosie, R.
AU - Nicolae, A.C.
AU - Gherghe, M.
AU - Gheorghe, D.C.
AU - Spandidos, D.A.
AU - Tsatsakis, A.
AU - Papasavva, M.
AU - Drakoulis, N.
JO - Oncology Letters
PY - 2020
VL - 19
TODO - 2
SP - 1537-1543
PB - Spandidos Publications
SN - 1792-1074, 1792-1082
TODO - 10.3892/ol.2019.11215
TODO - melatonin, adult;  antineoplastic activity;  Article;  cancer grading;  cancer staging;  clinical article;  controlled study;  diagnostic accuracy;  disease severity;  enzyme linked immunosorbent assay;  histopathology;  human;  human experiment;  human tissue;  limit of detection;  lymph node metastasis;  male;  middle aged;  mouth squamous cell carcinoma;  prediction;  receiver operating characteristic;  sensitivity and specificity;  solid phase extraction;  tumor volume
TODO - Melatonin, the primary hormone produced by the pineal gland, is intensely assessed for its anticancer properties. This study aimed to reveal the clinical significance of serum melatonin levels in predicting the severity of oral squamous cell carcinoma (OSCC). For this purpose, 40 male patients with OSCC and 30 healthy subjects were enrolled in this study. The serum levels of melatonin were determined by ELISA. The results revealed that the melatonin concentrations were significantly lower in the patients with OSCC compared with the controls (18.2 vs. 47.6 pg/ml, P<0.001). In addition, the serum melatonin levels had a high predictive accuracy for discriminating patients with OSCC with T-depth of invasion (DOI) II from the healthy controls (89.1%), as well as in discriminating patients with OSCC with nodal metastasis from those without nodal metastasis (83.8%). On the whole, the findings of this study suggest that the serum melatonin concentrations are closely related to the severity of OSCC and may thus be used to assess the different stages of oral cancer objectively and accurately. The present study also supports the conclusion that melatonin may be a potential therapeutic agent for use in the treatment of patients with OSCC. © 2020 Spandidos Publications. All rights reserved.
ER -