TY - JOUR
TI - Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition
AU - Kliemann, N.
AU - Murphy, N.
AU - Viallon, V.
AU - Freisling, H.
AU - Tsilidis, K.K.
AU - Rinaldi, S.
AU - Mancini, F.R.
AU - Fagherazzi, G.
AU - Boutron-Ruault, M.-C.
AU - Boeing, H.
AU - Schulze, M.B.
AU - Masala, G.
AU - Krogh, V.
AU - Sacerdote, C.
AU - de Magistris, M.S.
AU - Bueno-de-Mesquita, B.
AU - Weiderpass, E.
AU - Kühn, T.
AU - Kaaks, R.
AU - Jakszyn, P.
AU - Redondo-Sánchez, D.
AU - Amiano, P.
AU - Chirlaque, M.-D.
AU - Gurrea, A.B.
AU - Ericson, U.
AU - Drake, I.
AU - Nøst, T.H.
AU - Aune, D.
AU - May, A.M.
AU - Tjønneland, A.
AU - Dahm, C.C.
AU - Overvad, K.
AU - Tumino, R.
AU - Quirós, J.R.
AU - Trichopoulou, A.
AU - Karakatsani, A.
AU - La Vecchia, C.
AU - Nilsson, L.M.
AU - Riboli, E.
AU - Huybrechts, I.
AU - Gunter, M.J.
JO - International Journal  of Cancer
PY - 2020
VL - 147
TODO - 3
SP - 648-661
PB - Wiley-Liss, Inc.
SN - 0020-7136
TODO - 10.1002/ijc.32753
TODO - adult;  Article;  basal metabolic rate;  body mass;  breast cancer;  cancer risk;  colon cancer;  endometrium cancer;  esophageal adenocarcinoma;  female;  human;  male;  obesity;  pancreas cancer;  postmenopause;  priority journal;  thyroid cancer;  aged;  basal metabolic rate;  classification;  clinical trial;  complication;  Europe;  incidence;  metabolism;  middle aged;  multicenter study;  neoplasm;  nutritional assessment;  prospective study;  sexual characteristics, Adult;  Aged;  Basal Metabolism;  Europe;  Female;  Humans;  Incidence;  Male;  Middle Aged;  Neoplasms;  Nutrition Assessment;  Obesity;  Prospective Studies;  Sex Characteristics
TODO - Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness. © 2019 International Agency for Research on Cancer (IARC/WHO); licensed by UICC
ER -