TY - JOUR
TI - Effect of honey on glucose and insulin concentrations in obese girls
AU - Farakla, I.
AU - Koui, E.
AU - Arditi, J.
AU - Papageorgiou, I.
AU - Bartzeliotou, A.
AU - Papadopoulos, G.E.
AU - Mantzou, A.
AU - Papathanasiou, C.
AU - Dracopoulou, M.
AU - Papastamataki, M.
AU - Moutsatsou, P.
AU - Papassotiriou, I.
AU - Chrousos, G.P.
AU - Charmandari, E.
JO - European Journal of Clinical Investigation
PY - 2019
VL - 49
TODO - 2
SP - null
PB - Wiley-Blackwell Publishing Ltd
SN - 0014-2972, 1365-2362
TODO - 10.1111/eci.13042
TODO - alpha tocopherol;  apolipoprotein A1;  apolipoprotein B;  ascorbic acid;  C reactive protein;  cholesterol;  cytokine;  glucose;  high density lipoprotein;  insulin;  interleukin 10;  interleukin 12;  interleukin 1alpha;  interleukin 1beta;  interleukin 6;  interleukin 8;  lipid;  lipoprotein A;  low density lipoprotein;  monocyte chemotactic protein 1;  retinol;  triacylglycerol;  tumor necrosis factor;  biological marker;  glucose;  insulin;  sweetening agent, antioxidant activity;  Article;  body mass;  child;  childhood obesity;  clinical article;  controlled study;  diastolic blood pressure;  female;  glucose blood level;  honey;  human;  insulin blood level;  oral glucose tolerance test;  prepuberty;  priority journal;  scanning electron microscopy;  systolic blood pressure;  blood;  childhood obesity;  follow up;  glucose tolerance test;  metabolism;  randomized controlled trial, Biomarkers;  Blood Glucose;  Body Mass Index;  Child;  Female;  Follow-Up Studies;  Glucose;  Glucose Tolerance Test;  Honey;  Humans;  Insulin;  Pediatric Obesity;  Sweetening Agents
TODO - Background: Childhood obesity represents a major health problem of our century. The benefits of natural products, such as honey, in the management of obesity have gained renewed interest. In this study, we investigated the effect of honey on glucose and insulin concentrations in obese prepubertal girls. Materials and Methods: Thirty healthy obese girls aged 10.55 (±SEM:0.34) years with a mean body mass index (BMI) above the 97th centile for age (28.58 ± 1.40 kg/m2, BMI z-score 2.96) underwent a standard oral glucose tolerance test (OGTT) followed by an oral honey tolerance test (OHTT) 2 weeks later. Both solutions contained 75 g of glucose. Subsequently, subjects were randomized to receive either 15 g of honey or 15 g of marmalade daily, while both groups complied with dietetic instructions. Six months later all subjects were re-evaluated with an OGTT and an OHTT. Results: At the end of the study, all subjects demonstrated a significant reduction in BMI (27.57 ± 1.40, z-score: 2.54 vs 28.58 ± 1.40 kg/m2, z-score: 2.96, P < 0.001), however, there were no significant differences in BMI and all parameters tested between the group that received honey and the control group. The areas under the concentration–time curve for glucose and insulin for the entire population were significantly lower following ingestion of honey than glucose solution (P < 0.001) both at the beginning and at the end of study. Conclusions: These findings indicate that honey does not have an effect on stimulated plasma glucose and serum insulin concentrations compared with the standard glucose solution in obese prepubertal girls. © 2018 Stichting European Society for Clinical Investigation Journal Foundation
ER -