TY - JOUR
TI - In early pubertal boys, testosterone and LH are associated with improved anti-oxidation during an aerobic exercise bout
AU - Paltoglou, G.
AU - Avloniti, A.
AU - Chatzinikolaou, A.
AU - Stefanaki, C.
AU - Papagianni, M.
AU - Papassotiriou, I.
AU - Fatouros, I.G.
AU - Chrousos, G.P.
AU - Kanaka-Gantenbein, C.
AU - Mastorakos, G.
JO - Endocrine Development
PY - 2019
VL - 66
TODO - 2
SP - 370-380
PB - Humana Press Inc.
SN - null
TODO - 10.1007/s12020-019-02037-1
TODO - antioxidant;  carbonyl derivative;  catalase;  glutathione;  glutathione disulfide;  luteinizing hormone;  testosterone;  thiobarbituric acid reactive substance;  catalase;  follitropin;  glutathione;  luteinizing hormone;  testosterone;  thiobarbituric acid reactive substance, adolescent;  adolescent obesity;  aerobic exercise;  Article;  child;  controlled study;  cross-sectional study;  endocrine function;  human;  hypothalamic pituitary testicular axis;  major clinical study;  male;  observational study;  oxidation;  priority journal;  puberty;  blood;  childhood obesity;  exercise;  metabolism;  oxidative stress;  physiology;  puberty, Catalase;  Child;  Cross-Sectional Studies;  Exercise;  Follicle Stimulating Hormone;  Glutathione;  Humans;  Luteinizing Hormone;  Male;  Oxidative Stress;  Pediatric Obesity;  Puberty;  Testosterone;  Thiobarbituric Acid Reactive Substances
TODO - Purpose: To investigate the association of the hypothalamic-pituitary-testicular (HPT) axis with pro- and anti- oxidation, in relation to puberty and obesity in boys, before and after an aerobic exercise bout. Methods: This is a cross-sectional human observational study of 92 healthy normal-weight, obese pre- and early- pubertal boys that underwent a blood sampling, before, and after an aerobic exercise bout at 70% VO2max, until exhaustion. LH, FSH, total testosterone (tT) and markers of pro- (TBARS and PCs) and anti- (GSH, GSSG, GPX, catalase, TAC) oxidation were measured. Results: Baseline LH, FSH, and tT concentrations were greater in early, than in pre- pubertal boys, independently of weight status. Post-exercise, LH concentrations decreased in early pubertal boys while FSH concentrations did not change in any of the studied groups. Baseline and post-exercise tT concentrations were lower in obese than in normal-weight early pubertal boys, while baseline and post-exercise LH and FSH concentrations did not differ between these groups. Post-exercise tT concentrations increased in early pubertal obese boys. Baseline LH, FSH and tT concentrations correlated positively with baseline anti-oxidation markers concentrations in pre-pubertal boys. Baseline tT concentrations correlated positively with the increase of TAC concentrations in early pubertal normal-weight boys. In all boys, baseline LH concentrations were the best positive predictors for the exercise-associated increase of TAC concentrations. Conclusions: It appears that the HPT axis maturation during puberty (in particular its LH and testosterone components) is positively associated with the increase of anti-oxidation during a bout of aerobic exercise. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
ER -