TY - JOUR
TI - Predictors of incident hypertension in healthy non-diabetic postmenopausal women with normal renal function
AU - Stamatelopoulos, K.
AU - Apostolakis, M.
AU - Augoulea, A.
AU - Paschou, S.A.
AU - Armeni, E.
AU - Panoulis, K.
AU - Bakas, P.
AU - Georgiopoulos, G.
AU - Kaparos, G.
AU - Rizos, D.
AU - Lambrinoudaki, I.
JO - Gynecological Endocrinology
PY - 2019
VL - 35
TODO - 12
SP - 1063-1066
PB - Taylor and Francis Ltd.
SN - 0951-3590, 1473-0766
TODO - 10.1080/09513590.2019.1630607
TODO - antihypertensive agent;  cholesterol;  triacylglycerol, adult;  anthropometric parameters;  Article;  blood pressure;  blood sampling;  cardiovascular risk;  cholesterol level;  cohort analysis;  controlled study;  diastolic blood pressure;  female;  follow up;  Greece;  human;  hypertension;  insulin resistance;  kidney function;  major clinical study;  obesity;  parity;  postmenopause;  priority journal;  retrospective study;  risk factor;  systolic blood pressure;  triacylglycerol level;  ultrasound;  arterial wall thickness;  hypercholesterolemia;  hypertension;  hypertriglyceridemia;  incidence;  middle aged;  multivariate analysis, Adiposity;  Carotid Intima-Media Thickness;  Cohort Studies;  Female;  Humans;  Hypercholesterolemia;  Hypertension;  Hypertriglyceridemia;  Incidence;  Insulin Resistance;  Middle Aged;  Multivariate Analysis;  Obesity;  Parity;  Postmenopause;  Retrospective Studies;  Risk Factors
TODO - Introduction: We aimed to investigate the incidence of hypertension and to identify potential risk factors in healthy, non-diabetic recently postmenopausal Greek women with normal renal function. Patients and methods: This retrospective cohort study evaluated 141 recently postmenopausal women at baseline and annually thereafter (follow-up time: 1 to 8 years). Blood samples were obtained, and ultrasound evaluations were performed at baseline. A detailed medical history, anthropometric parameters, blood pressure and cardiovascular risk factors were recorded for every woman at each visit. Incident hypertension was defined as the first occurrence of office systolic or diastolic blood pressure, measured at 2 different visits within 2 months or history of initiation of antihypertensive medication. Results: Incident hypertension was diagnosed in 30 out of 141 women (21.3%). The median time to incident hypertension was 3.5 years. Adiposity, elevated cholesterol and triglyceride levels, insulin resistance and parity were positively associated with incident hypertension. In multivariate analysis, however, obesity and insulin resistance were the only statistically significant variables associated with more than 3-fold and 2-fold respectively increased risk of incident hypertension (HOMA-IR, O.R = 1.988, p-value =.043; obesity, O.R = 3.746, p-value =.019). Conclusion: A significant proportion of women entering the menopause present incident hypertension and this is mostly associated with obesity and insulin resistance. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
ER -