TY - JOUR
TI - Point-of-need molecular processing of biosamples using portable instrumentation to reduce turnaround time
AU - Kambouris, M.E.
AU - Siamoglou, S.
AU - Kordou, Z.
AU - Milioni, A.
AU - Vassilakis, S.
AU - Goudoudaki, S.
AU - Kritikou, S.
AU - Manoussopoulos, Y.
AU - Velegraki, A.
AU - Patrinos, G.P.
JO - Biosafety and Health
PY - 2020
VL - 2
TODO - 3
SP - 177-182
PB - Elsevier B.V.
SN - null
TODO - 10.1016/j.bsheal.2020.06.001
TODO - null
TODO - Infectious agents, both standard and emerging or engineered, might initiate outbreaks with global impact and/or existential- level threat potential. Such agents might infect human, livestock, exploitable plant cultures or the environment at large. Instead of responding by sampling teams which may also carry out prolonged surveillance, a more effective concept is to pre-process the samples, possibly to nucleic acid extract so as to transport them without biological risks by standard channels, or to process them up to a point and return the results, leaving the samples which only need specialized tests and dedicated equipment. In this context a portable device, allowing multiple routine and crisis -management applications due to its inherent flexibility, is scrutinized against alternatives and possible needs so as to develop a novel standard of surveillance and intervention, meant to facilitate containment by providing faster much more reliable laboratory results at a fraction of older generation mobile nucleic acids analyzers. Additional steps, such as agarose in pills and buffers pre-packaged in expendable syringes with pistons locked by improvised safety features may improve the Complexity Level of the whole system so as to make it appealing to intervention/crisis management personnel, while the instrument proper may double as backup for respective benchtop devices. © 2020 Elsevier B.V.
ER -