TY - JOUR
TI - Intracerebroventricular endothelin receptor-a blockade in rats decreases phase-II ventricular tachyarrhythmias during acute myocardial infarction
AU - Lekkas, P.
AU - Georgiou, E.S.
AU - Kontonika, M.
AU - Mouchtouri, E.-T.
AU - Mourouzis, I.
AU - Pantos, C.
AU - Kolettis, T.M.
JO - Physiological Research
PY - 2019
VL - 68
TODO - 5
SP - 867-871
PB - Czech Academy of Sciences
SN - null
TODO - 10.33549/physiolres.934135
TODO - cyclo(Trp-Asp-Pro-Val-Leu);  cyclopeptide;  endothelin A receptor;  endothelin A receptor antagonist, animal;  brain ventricle;  complication;  disease model;  drug effect;  heart infarction;  heart ventricle extrasystole;  heart ventricle tachycardia;  intracerebroventricular drug administration;  metabolism;  pathophysiology;  Wistar rat, Animals;  Cerebral Ventricles;  Disease Models, Animal;  Endothelin A Receptor Antagonists;  Injections, Intraventricular;  Myocardial Infarction;  Peptides, Cyclic;  Rats, Wistar;  Receptor, Endothelin A;  Tachycardia, Ventricular;  Ventricular Premature Complexes
TODO - Endothelin alters central sympathetic responses, but the resultant effects on arrhythmogenesis are unknown. We examined ventricular tachyarrhythmias after endothelin receptor-A blockade in the brain of Wistar rats with acute myocardial infarction. For this aim, BQ-123 (n=6) or phosphate-buffered saline (n=6) were injected intracerebroventricularly. After 10 min, the left coronary artery was ligated, followed by implantation of telemetry transmitters. Electrocardiography and voluntary activity (as a surrogate of acute left ventricular failure) were continuously monitored for 24 h. Infarct-size was similar in the two groups. There were fewer episodes of ventricular tachyarrhythmias of shorter average duration in treated rats, leading to markedly shorter total duration (12.3±8.9 s), when compared to controls (546.2±130.3 s). Voluntary activity increased in treated rats during the last hours of recording, but bradyarrhythmic episodes were comparable between the two groups. Endothelin receptor-A blockade in the brain of rats decreases the incidence of ventricular tachyarrhythmias post-ligation, without affecting bradyarrhythmic episodes. These findings call for further research on the pathophysiologic role of endothelin during acute myocardial infarction. © 2019 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
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