TY - JOUR
TI - Re-analysis of human immunodeficiency virus type 1 isolates from Cyprus
and Greece, initially designated `subtype I', reveals a unique complex
A/G/H/K/? mosaic pattern
AU - Paraskevis, D
AU - Magiorkinis, M
AU - Vandamme, AM
AU - Kostrikis, LG and
AU - Hatzakis, A
JO - Journal of General Virology
PY - 2001
VL - 82
TODO - 3
SP - 575-580
PB - SOC GENERAL MICROBIOLOGY
SN - 0022-1317, 1465-2099
TODO - 10.1099/0022-1317-82-3-575
TODO - null
TODO - Human immunodeficiency virus type 1 (HIV-1) has been classified into
three main groups and 11 distinct subtypes. Moreover, several
circulating recombinant forms (CRFs) of HIV-1 have been recently
documented to have spread widely causing extensive HIV-1 epidemics. A
subtype, initially designated I (CRF04_cpx), was documented in Cyprus
and Greece and was found to comprise regions of sequence derived from
subtypes A and G as well as regions of unclassified sequence. Reanalysis
of the three full-length CRF04_cpx sequences that were available
revealed a mosaic genomic organization of unique complexity comprising
regions of sequence from at least five distinct subtypes, A, G, H, K and
unclassified regions. These strains account for approximately 2% of the
total HIV-1-infected population in Greece, thus providing evidence of
the great capability of HIV-1 to recombine and produce highly divergent
strains which can be spread successfully through different infection
routes.
ER -