TY - JOUR
TI - Amniotic membrane inlay and overlay grafting for corneal epithelial
defects and stromal ulcers
AU - Letko, E
AU - Stechschulte, SU
AU - Kenyon, KR
AU - Sadeq, N
AU - Romero, TR
AU - and Samson, CM
AU - Nguyen, QD
AU - Harper, SL
AU - Primack, JD
AU - Azar,
AU - DT
AU - Gruterich, M
AU - Dohlman, CH
AU - Baltatzis, S
AU - Foster, CS
JO - ARCHIVES OF OPHTHALMOLOGY - CHICAGO
PY - 2001
VL - 119
TODO - 5
SP - 659-663
PB - AMER MEDICAL ASSOC
SN - 0003-9950
TODO - 10.1001/archopht.119.5.659
TODO - null
TODO - Objectives: To determine the effect of amniotic membrane transplantation
(AMT) on persistent corneal epithelial defects (PEDs) and to compare the
efficacy between inlay and overlay techniques.
Methods: Thirty patients (30 eyes) underwent AMT for FED. The use of AMT
was restricted to patients in whom all previous measures, including
bandage contact lens and tarsorrhaphy, had failed. The amniotic membrane
was placed on the surface of the cornea in overlay (group A) or inlay
(group B) fashion.
Results: The FED healed after the first AMT in 21 eyes (70%) within an
average of 25.5 days after surgery and recurred in 6 eyes (29%). Among
the 22 eyes treated with an overlay AMT (group A), the FED healed after
the first AMT in 14 eyes (64%) within an average of 24.5 days and
recurred in 4 eyes (29%). Among the 8 eyes treated with an inlay AMT
(group B), the FED healed within an average of 27.4 days after AMT,
which did not statistically significantly differ from group A (P = .72).
The FED healed after the first AMT in 7 eyes (88%) and recurred in 2
(29%) of 7 eyes.
Conclusions: The AMT can be helpful in the treatment of FED in which all
other conventional management has failed. However, the success rate in
our study was not as high as that previously reported, and our results
showed a high incidence of recurrences of epithelial defects. We did not
find any difference between overlay and inlay techniques in terms of
healing time and recurrence rate.
ER -