TY - JOUR
TI - Dermatitis during radiation for vulvar carcinoma: prevention and
treatment with granulocyte-macrophage colony-stimulating factor
impregnated gauze
AU - Kouvaris, JR
AU - Kouloulias, VE
AU - Plataniotis, GA
AU - Balafouta, EJ
AU - and Vlahos, LJ
JO - Wound Repair and Regeneration
PY - 2001
VL - 9
TODO - 3
SP - 187-193
PB - BLACKWELL SCIENCE PUBL INC CAMBRIDGE
SN - 1067-1927, 1524-475X
TODO - 10.1046/j.1524-475x.2001.00187.x
TODO - null
TODO - The aim of this study was to determine the effectiveness of
granulocyte-macrophage colony-stimulating factor (GMCSF) impregnated
gauze in preventing or healing radiation-induced dermatitis, Sixty-one
patients were irradiated for vulvar carcinoma, Thirty-seven applied
steroid cream at irradiated areas throughout radiotherapy (Group A) and
24 patients applied additionally GM-CSF impregnated gauze (40 mug/cm(2)
of skin-irradiated area, twice per day) in addition to the steroid
cream, after 20Gy of irradiation (Group B). The score of skin reactions
(P=0.008, chi(2) test) and the time interval of radiotherapy
interruption (P=0.037, Mann-Whitney U test) were statistically
significantly reduced in Group B patients, Multivariate analysis of
variance showed for this group not only a significant reduction in the
Sum of Gross Dermatitis Scoring (P<0.001, adjusted for Duration of
Dermatitis) but also a significant reduction of the healing time
(P=0.02, adjusted for Sum of Gross Dermatitis Scoring). The pain grading
was less (P=0.014, chi(2) test) and pain reduction was noticed sooner
after the application of GM-CSF impregnated gauze (P=0.0017,
Mann-Whitney U test). Multivariate logistic regression analysis showed
that the only significant effect on dermatitis score is due to Body Mass
Index (P=0.034) and the application of GM-CSF (P=0.008), GM-CSF
impregnated gauze can be effective in preventing and healing
radiation-induced dermatitis and in reducing the interruption intervals
of radiotherapy for vulvar carcinomas.
ER -