TY - JOUR
TI - Frontal lobe dysfunction in amyotrophic lateral sclerosis
AU - Evdokimidis, I
AU - Constantinidis, TS
AU - Gourtzelidis, P
AU - Smyrnis, N
AU - and Zalonis, I
AU - Zis, PV
AU - Andreadou, E
AU - Papageorgiou, C
JO - Journal of the Neurological Sciences
PY - 2002
VL - 195
TODO - 1
SP - 25-33
PB - Elsevier
SN - 0022-510X
TODO - 10.1016/S0022-510X(01)00683-9
TODO - ALS; motor neuron; frontal lobe; anti-saccade; remembered saccade;
working memory
TODO - The aim of the present study was to investigate the involvement of
frontal lobe dysfunction in amyotrophic lateral sclerosis (ALS) using
ocular motor paradigms and neuropsychological testing. Fifty-one
patients with ALS participated in the following ocular motor tasks: (1)
a three-choice task and (2) a remembered saccade task. The patients
underwent a clinical and neuropsychological evaluation. One-third of ALS
patients presented with signs of frontal dysfunction, as determined by
their high distractibility factors (DF) in the three-choice task and
their performances in both the Wisconsin and Stroop tests. ALS patients
exhibited longer latencies to eye movement than controls in the
performance of the remembered saccade task, specifically in performance
of both remembered and delayed saccades, but saccade accuracy was not
impaired. Finally, performance indices of the ocular motor tasks, in
particular the DF, was correlated only with the degree of dysarthria.
(C) 2002 Elsevier Science B.V. All rights reserved.
ER -