TY - JOUR
TI - No major schizophrenia locus detected on chromosome 1q in a large
multicenter sample
AU - Levinson, DF
AU - Holmans, PA
AU - Laurent, C
AU - Riley, B
AU - Pulver, AE
AU - and Gejman, PV
AU - Schwab, SG
AU - Williams, NM
AU - Owen, MJ and
AU - Wildenauer, DB
AU - Sanders, AR
AU - Nestadt, G
AU - Mowry, BJ
AU - Wormley,
AU - B
AU - Bauche, S
AU - Soubigou, S
AU - Ribble, R
AU - Nertney, DA
AU - Liang,
AU - KY
AU - Martinolich, L
AU - Maier, W
AU - Norton, N
AU - Williams, H and
AU - Albus, M
AU - Carpenter, EB
AU - deMarchi, N
AU - Ewen-White, KR
AU - Walsh,
AU - D
AU - Jay, M
AU - Deleuze, JF
AU - O'Neill, FA
AU - Papadimitriou, G and
AU - Weilbaecher, A
AU - Lerer, B
AU - O'Donovan, MC
AU - Dikeos, D and
AU - Silverman, JM
AU - Kendler, KS
AU - Mallet, J
AU - Crowe, RR
AU - Walters, M
JO - SCIENCE CHINA Information Sciences
PY - 2002
VL - 296
TODO - 5568
SP - 739-741
PB - AMER ASSOC ADVANCEMENT SCIENCE
SN - null
TODO - 10.1126/science.1069914
TODO - null
TODO - Reports of substantial evidence for genetic linkage of schizophrenia to
chromosome 1q were evaluated by genotyping 16 DNA markers across 107
centimorgans of this chromosome in a multicenter sample of 779
informative schizophrenia pedigrees. No significant evidence was
observed for such linkage, nor for heterogeneity in allele sharing among
the eight individual samples. Separate analyses of European-origin
families, recessive models of inheritance, and families with larger
numbers of affected cases also failed to produce significant evidence
for linkage. If schizophrenia susceptibility genes are present on
chromosome 1q, their population-wide genetic effects are likely to be
small.
ER -