TY - JOUR
TI - Liver pathology and cell proliferation after octreotide administration
following partial hepatectomy in rats - An experimental study
AU - Papalampros, E
AU - Felekouras, ES
AU - Filis, K
AU - Angelopoulou, R and
AU - Kourelis, T
AU - Tsamandas, AC
AU - Bastounis, E
JO - Digestive Diseases and Sciences
PY - 2002
VL - 47
TODO - 9
SP - 1953-1958
PB - KLUWER ACADEMIC/PLENUM PUBL
SN - 0163-2116, 1573-2568
TODO - 10.1023/A:1019687804859
TODO - octreotide; hepatectomy; liver regeneration; rats
TODO - Octreotide is a somatostatin analog introduced for clinical use that
inhibits the growth of various tumors in rats. This study investigates
liver pathology after octreotide treatment following partial (2/3)
hepatectomy in rats. Thirty rats, weighing 250-300 g underwent partial
hepatectomy and were divided in to two groups. Group A (N = 25) received
octreotide subcutaneously [2 mug Sandostatin (Sandoz) in 1 ml normal
saline every 12 hr for 15 days]. Group B (N = 5) was injected with 1 ml
normal saline subcutaneously every 12 hr for the same time period;
animals in this group were used as controls. At the end of the
experiment rats were sacrificed and liver tissue was obtained for
pathologic examination. Liver sections from group A (octreotide
administration) showed extensive cholangiolar and fibrous tissue
proliferation in the hepatectomy area, and hypertrophy and swelling of
Kupffer cells in the liver parenchyma. Sections from the hepatectomy
surface from group B (controls) displayed signs of liver regeneration.
Proliferation activity (Ki-67(+) cells) was higher in the cholangiolar
epithelium in group A and in hepatocytes in group B. In conclusion, the
results of this study show that octreotide inhibits liver regeneration,
which occurs after partial hepatectomy in rats and enhances hyperplasia
of cholangiolar and fibrous tissue.
ER -