TY - JOUR
TI - Application of a ketogenic diet in children with autistic behavior:
Pilot study
AU - Evangeliou, A
AU - Vlachonikolis, I
AU - Mihailidou, H
AU - Spilioti, M and
AU - Skarpalezou, A
AU - Makaronas, N
AU - Prokopiou, A
AU - Christodoulou, P
AU - and Liapi-Adamidou, G
AU - Helidonis, E
AU - Sbyrakis, S
AU - Smeitink, J
JO - Journal of Child Neurology
PY - 2003
VL - 18
TODO - 2
SP - 113-118
PB - SAGE Publications Inc.
SN - 0883-0738, 1708-8828
TODO - 10.1177/08830738030180020501
TODO - null
TODO - A pilot prospective follow-up study of the role of the ketogenic diet
was carried out on 30 children, aged between 4 and 10 years, with
autistic behavior. The diet was applied for 6 months, with continuous
administration for 4 weeks, interrupted by 2-week diet-free intervals.
Seven patients could not tolerate the diet, whereas five other patients
adhered to the diet for I to 2 months and then discontinued it. Of the
remaining group who adhered to the diet, 18 of 30 children (60%),
improvement was recorded in several parameters and in accordance with
the Childhood Autism Rating Scale. Significant improvement (> 12 units
of the Childhood Autism Rating Scale) was recorded in two patients
(pre-Scale: 35.00 +/- 1.41 [mean +/- SD]), average improvement (> 8-12
units) in eight patients (pre-Scale: 41.88 +/- 3.14[mean SD]), and
minor improvement (2-8 units) in eight patients (pre-Scale: 45.25 +/-
2.76 [mean +/- SD]). Although these data are very preliminary, there
is some evidence that the ketogenic diet may be used in autistic
behavior as an additional or alternative therapy.
ER -