TY - JOUR
TI - Endothelin-1 in children with acute poststreptococcal glomerulonephritis
and hypertension
AU - Nicolaidou, P
AU - Georgouli, H
AU - Matsinos, Y
AU - Psychou, F and
AU - Messaritaki, A
AU - Gourgiotis, D
AU - Zeis, P
JO - Pediatrics International
PY - 2003
VL - 45
TODO - 1
SP - 35-38
PB - Wiley-Blackwell Publishing Asia
SN - 1328-8067, 1442-200X
TODO - 10.1046/j.1442-200X.2003.01661.x
TODO - acute poststreptococcal glomerulonephritis; Endothelin-1; hypertension
TODO - Background : Endothelin-1 (ET-1), the most potent vasoconstrictor
peptide, is known to play a role in arterial hypertension. In patients
with acute poststreptococcal glomerulonephritis (APSGN) an increase in
the production of ET-1 is suspected due to damaged endothelium, platelet
activation and increased thrombin production in the glomeruli. The aim
of the present study was to investigate whether the levels of plasma
ET-1 are elevated in children with APSGN. Furthermore, we examined the
association between plasma ET-1 levels and blood pressure levels in the
same children.
Methods : We studied 18 children (14 boys) with APSGN (mean age
7.44+/-2.82 years). Fourteen healthy children served as controls. The
following parameters were evaluated: plasma ET-1, plasma atrial
natriuretic peptide (ANP), plasma renin (Rn), serum aldosterone (Aldo),
creatinine clearance (Ccr) and fractional excretion of sodium (FENa).
Results : The mean plasma ET-1 concentrations were higher in patients
with APSGN (3.39+/-1.86 pg/mL) compared to controls (1.40+/-0.15 pg/mL;
P =0.0001). Patients with APSGN also had higher plasma ANP
concentrations (41.67+/-27.99 pg/mL) than the controls (22.80+/-4.24
pg/mL; P =0.011). Plasma Rn concentrations were lower in patients
(24.54+/-16.34 muU/mL) compared to controls (56.76+/-32.36 muU/mL; P
=0.027). A positive correlation was found between ET-1 plasma
concentrations and the height of systolic or diastolic blood pressure (r
=0.57, P =0.013 and r =0.53, P =0.023, respectively).
Conclusions : Our results suggest that increased plasma ET-1
concentrations may play an important role in the pathogenesis of
hypertension in children with acute poststreptococcal
glomerulonephritis.
ER -