TY - JOUR
TI - Effect of losartan on insulin plasma concentrations and LPL activity in
adipose tissue of hypertensive rats
AU - Saranteas, T
AU - Lolis, E
AU - Mourouzis, C
AU - Potamianou, A and
AU - Tesseromatis, C
AU - Varonos, D
JO - Hormone and Metabolic Research
PY - 2003
VL - 35
TODO - 3
SP - 164-168
PB - Georg Thieme Verlag KG
SN - 0018-5043, 1439-4286
TODO - 10.1055/s-2003-39071
TODO - lipoprotein lipase activity; losartan; insulin; rats
TODO - The aim of this study is to determine the effect of losartan on insulin
and angiotensin 11 (Ang 11) concentrations in plasma as well as on
lipoprotein lipase activity (LPL) and angiotensin 11 content in the
adipose tissue of hypertensive rats. Fifty male rats were divided in
five groups. Group A served as controls. Group B underwent renal artery
stenosis. Group C were administered losartan (10 mg/kg/day) per OS,
while Fats in group D were submitted to renal artery stenosis and were
treated with losartan as above. Group E was used as sham-operated
control. The animals were sacrificed at day 21. Blood samples were
collected, and perirenal adipose tissue was isolated. Furthermore,
adrenal’s were removed and their relative weight (adrenal weight/body
weight) was used as an index of sympathetic stimulation. According to
our results, renovascular hypertension resulted in lower insulin
concentrations and higher Ang If content in plasma. In hypertensive
rats, LPL activity was decreased, while the adrenals’ relative weight
was elevated. On the other hand, losartan administration resulted in
normalization of insulin concentrations in plasma and adrenals’ relative
weight, with consequent up regulation of LPL activity in adipose tissue.
In conclusion, renovascular hypertension interferes in lipid metabolism
by reducing LPL activity in adipose tissue, while losartan
administration reverses this effect by enhancing insulin release and
reducing sympathetic nervous system (SNS) stimulation.
ER -