TY - JOUR
TI - In vitro activity of telithromycin (HMR 3647) against Greek
Streptococcus pyogenes and Streptococcus pneumoniae clinical isolates
with different macrolide susceptibilities
AU - Ioannidou, S
AU - Tassios, PT
AU - Zachariadou, L
AU - Salem, Z and
AU - Kanelopoulou, M
AU - Kanavaki, S
AU - Chronopoulou, G
AU - Petropoulou, N
AU - and Foustoukou, M
AU - Pangalis, A
AU - Trikka-Graphakos, E and
AU - Papafraggas, E
AU - Vatopoulos, AC
JO - Clinical Microbiology and Infection
PY - 2003
VL - 9
TODO - 7
SP - 704-707
PB - Wiley-Blackwell Publishing Ltd
SN - 1198-743X
TODO - 10.1046/j.1469-0691.2003.00572.x
TODO - streptococci; macrolide resistance; telithromycin
TODO - The susceptibilities to macrolides and telithromycin of 161
Streptococcus pyogenes and 145 Streptococcus pyogenes strains,
consecutively isolated from five Greek hospitals, were determined by
Etest. Moreover, mechanisms of resistance to macrolides were
phenotypically and genetically determined by double disk induction test
and PCR, respectively. Of the S. pneumoniae and S. pyogenes isolates,
42.8% and 30.8%, respectively, were found to be resistant to
erythromycin. Of the erythromycin-resistant S. pneumoniae and S.
pyogenes isolates, 57.5% and 59.5%, respectively, displayed the M
phenotype and harbored the mefA/E gene. Telithromycin was found to be
more active than both erythromycin and clarithromycin against both
species, with considerably lower MIC50 and MIC90 values.
ER -