TY - JOUR
TI - Lack of effect of acute repaglinide administration on postprandial
lipaemia in patients with type 2 diabetes mellitus
AU - Tentolouris, N
AU - Kolia, M
AU - Tselepis, AD
AU - Perea, D
AU - Kitsou, E
AU - and Kyriaki, D
AU - Tambaki, AP
AU - Karabina, SP
AU - Sala, C and
AU - Fragoulopoulos, E
AU - Katsilambros, N
JO - Experimental and Clinical Endocrinology & Diabetes
PY - 2003
VL - 111
TODO - 6
SP - 370-373
PB - JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
SN - 0947-7349, 1439-3646
TODO - 10.1055/s-2003-42729
TODO - repaglinide; type 2 diabetes mellitus; triglycerides; postprandial
triglyceridaemia; lipoprotein subfractions
TODO - The effect of acute repaglinide administration (2 mg) on postprandial
glycaemia and lipaemia has been examined in 20 subjects with type 2
diabetes mellitus. Each subject received in the morning, after a 12 to
14 h fast, a standard mixed meal (total energy 783 kcal), preceded by
one tablet of 2 mg repaglinide or placebo. Chylomicrons and
chylomicron-deficient plasma were prepared by ultracentrifugation.
Triglyceride levels in CM fraction (CM-triglycerides) in total plasma as
well as in CM-deficient plasma (non-CM-triglycerides) were determined. A
significant reduction in postprandial glycaemia was observed after
repaglinide administration compared to placebo (p < 0.001). Plasma
concentrations of total triglycerides, CM-triglycerides,
non-CM-triglycerides, free fatty acids and the other plasma lipids
measured, were not significantly different between the two phases of the
study. It is concluded that, in contrast to sulphonylureas, acute
repaglinide administration does not improve postprandial lipaemia in
patients with type 2 diabetes.
ER -