TY - JOUR
TI - Urinary excretion of endothelin-1 in children with absorptive idiopathic
hypercalciuria
AU - Nicolaidou, P
AU - Georgouli, H
AU - Getsi, V
AU - Tsapra, H
AU - Psychou, F
AU - and Matsinos, YG
AU - Zeis, PM
AU - Gourgiotis, D
JO - Pediatric Nephrology
PY - 2003
VL - 18
TODO - 11
SP - 1157-1160
PB - Springer-Verlag
SN - 0931-041X, 1432-198X
TODO - 10.1007/s00467-003-1263-5
TODO - endothelin; calcium; hypercalciuria
TODO - Urinary excretion of endothelin-1 (ET-1) and plasma ET-1 were measured
in 21 children with absorptive idiopathic hypercalciuria (AIH) and 22
controls. The absorptive type of idiopathic hypercalciuria was
determined by a calcium loading test. Daily urinary excretion of ET-1
and urinary ET-1/creatinine ratio were significantly increased (P=0.005
and P=0.007, respectively) in patients with AIH (9,274+/-6,444 pg/24 h
and 14.04+/-9.52 pg/mg, respectively) compared with controls
(4,699+/-2,120 pg/24 h and 7.36+/-4.71 pg/mg, respectively). Plasma ET-1
levels were significantly lower in patients with AIH (0.84+/-0.64 pg/ml)
than in controls (1.54+/-0.54 pg/ml, P=0.0001). In conclusion, patients
with AIH had increased urinary ET-1 excretion and decreased plasma ET-1
levels. This is most likely due to the decreased reabsorption of ET-1 in
the renal tubule and increased renal production.
ER -