TY - JOUR
TI - Occupation and bladder cancer among men in Western Europe
AU - Kogevinas, M
AU - `t Mannetje, A
AU - Cordier, S
AU - Ranft, U and
AU - Gonzalez, CA
AU - Vineis, P
AU - Chang-Claude, J
AU - Lynge, E and
AU - Wahrendorf, J
AU - Tzonou, A
AU - Jockel, KH
AU - Serra, C
AU - Porru, S and
AU - Hours, M
AU - Greiser, E
AU - Bo, P
JO - Cancer Causes and Control
PY - 2003
VL - 14
TODO - 10
SP - 907-914
PB - KLUWER ACADEMIC PUBL
SN - 0957-5243, 1573-7225
TODO - 10.1023/B:CACO.0000007962.19066.9c
TODO - bladder neoplasms; occupation
TODO - Objectives: We examined which occupations and industries are currently
at high risk for bladder cancer in men.
Methods: We combined data from 11 case - control studies conducted
between 1976 - 1996 in six European countries. The study comprised 3346
incident cases and 6840 controls, aged 30 - 79 years. Lifetime
occupational and smoking histories were examined using common coding.
Results: Odds ratios for eight a priori defined high-risk occupations
were low, and with the exception of metal workers and machinists ( OR =
1.16, 95% CI = 1.02 - 1.32), were not statistically significant. Higher
risks were observed for specific categories of painters, metal, textile
and electrical workers, for miners, transport operators,
excavating-machine operators, and also for non-industrial workers such
as concierges and janitors. Industries entailing a high risk included
salt mining, manufacture of carpets, paints, plastics and industrial
chemicals. An increased risk was found for exposure to PAHs ( OR for
highest exposure tertile = 1.23, 95% CI = 1.07 - 1.4). The risk
attributable to occupation ranged from 4.2 to 7.4%, with an estimated
4.3% for exposure to PAHs.
Conclusions: Metal workers, machinists, transport equipment operators
and miners are among the major occupations contributing to occupational
bladder cancer in men in Western Europe. In this population one in 10 to
one in 20 cancers of the bladder can be attributed to occupation.
ER -