TY - JOUR
TI - Failure to eradicate Group A beta-haemolytic streptococci (GABHS) from
the upper respiratory tract after antibiotic treatment
AU - Kafetzis, DA
AU - Liapi, G
AU - Tsolia, M
AU - Aoudi, H
AU - Mathioudakis, J
AU - and Paraskakis, I
AU - Bairamis, T
JO - International Journal of Antimicrobial Agents
PY - 2004
VL - 23
TODO - 1
SP - 67-71
PB - Elsevier
SN - 0924-8579
TODO - 10.1016/j.ijantimicag.2003.05.015
TODO - tonsillitis; streptococcal; eradication; penicillin; cefprozil;
clarithromycin
TODO - :The clinical efficacy, safety and bacteriological eradication of Group
A p-haemolytic streptococci (GABHS) from the throat was studied after
treatment of streptococcal tonsillopharyngitis with three commonly used
oral antibiotics in a prospective, open labelled, comparative,
randomised trial of 265 evaluable patients seen in one centre. All three
antibiotics were administered in the recommended doses; penicillin V q8
hourly and clarithromycin q12 hourly were given for 10 days and
cefprozil q12 hourly for 5 days. Clinical results and adverse events
were similar for all three antibiotics used, with a prompt clinical
outcome of >95%. Cefprozil had the best bacteriological eradication
rate (failed to eradicate: 13.2, 15.1, 2.3; relapses: 13.2, 11.4, 5.7%,
for penicillin, clarithromycin and cefprozil, respectively). Oral
penicillin remains a clinically effective and safe antibiotic for the
treatment of streptococcal pharyngitis. However, compliance and
convenience for parents and children when they are asked to follow a 10
days course, especially when the patient has improved from the second or
third day, together with the high incidence of bacteriological
eradication failures, is an issue. (C) 2003 Elsevier B.V. and the
International Society of Chemotherapy. All rights reserved.
ER -