TY - JOUR
TI - Expression of proliferating cell nuclear antigen (PCNA) in multiple
myeloma: Its relationship to bone marrow microvessel density and other
factors of disease activity
AU - Alexandrakis, MG
AU - Passam, FH
AU - Pappa, CA
AU - Dambaki, C and
AU - Sfakiotaki, G
AU - Alegakis, AK
AU - Kyriakou, DS
AU - Stathopoulos, E
JO - International Journal of Immunopathology and Pharmacology
PY - 2004
VL - 17
TODO - 1
SP - 49-56
PB - SAGE Publications Inc.
SN - 0394-6320
TODO - 10.1177/039463200401700107
TODO - multiple myeloma; cell proliferation; PCNA; angiogenesis; microvessel
density; interleukin-6
TODO - The expression of the proliferating cell nuclear antigen (PCNA) was
studied in plasma cells in bone marrow biopsies from patients with
multiple myeloma (MM) using a double immunostaining method. In the same
samples, microvessel density (MVD), after staining with anti-CD34
antibodies, was determined before and after chemotherapy. The
correlation of PCNA expression and MVD with other myeloma parameters
(clinical stage, bone marrow plasma cell infiltration and serum
interleukin -6 (IL-6)) was also investigated.
The study population included 51 newly diagnosed MM patients, 12
patients in plateau phase after treatment and 15 normal controls.
Pretreatment mean +/- SE values of PCNA, MVD, plasma cell infiltration
and serum IL-6 were significantly higher than post treatment values and
controls. Pretreatment PCNA expression correlated significantly with
bone marrow MVD (p<0.05) plasma cell infiltration (p<0.01) and IL-6
(p<0.01).
These findings show that the proliferative activity of plasma cells is
related to the angiogenic activity in the bone marrow of multiple
myeloma patients. Both PCNA and MVD correlate with markers of disease
activity thus may provide additional information when included in the
initial evaluation of myeloma bone marrow biopsies.
ER -