TY - JOUR
TI - Thyroid hormone and phenotypes of cardioprotection
AU - Pantos, C
AU - Malliopoulou, V
AU - Varonos, DD
AU - Cokkinos, DV
JO - Basic Research in Cardiology
PY - 2004
VL - 99
TODO - 2
SP - 101-120
PB - Springer Berlin Heidelberg
SN - 0300-8428, 1435-1803
TODO - 10.1007/s00395-003-0449-0
TODO - thyroid hormone; cardiovascular system; phenotype of cardioprotection;
intracellular kinases; ischaemia and reperfusion
TODO - Thyroid hormone has multiple effects on the cardiovascular system with
important physiological consequences. Several genes that encode
important regulatory and structural proteins in the heart have been
shown to be thyroid hormone responsive. More notably, certain effects of
thyroid hormone have been exploited therapeutically. Thyroid hormone is
currently being evaluated as an inotrope and vasodilator in various
clinical settings. Furthermore, new information has been recently
accumulated on the role of thyroid hormone in the response of the heart
to ischaemic stress. In fact, hyperthyroid and hypothyroid hearts
display a phenotype of cardioprotection against ischaemia-reperfusion.
Based on this evidence, the various actions of thyroid hormone on the
cardiovascular system are highlighted in this review. Thyroid hormone,
although limited by its adverse effects, might prove a suitable
treatment for cardiovascular illnesses. Various thyroid hormone
analogues are currently under development.
ER -