TY - JOUR
TI - Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
AU - Gonos, E.S.
AU - Kapetanou, M.
AU - Sereikaite, J.
AU - Bartosz, G.
AU - Naparlo, K.
AU - Grzesik, M.
AU - Sadowska-Bartosz, I.
JO - Aging (Albany NY)
PY - 2018
VL - 10
TODO - 5
SP - 868-901
PB - Impact Journals, LLC
SN - null
TODO - 10.18632/aging.101450
TODO - aging;  animal;  brain disease;  halogenation;  human;  metabolism;  oxidative stress;  pathophysiology;  physiology;  protein carbonylation;  protein processing, Aging;  Animals;  Brain Diseases;  Halogenation;  Humans;  Oxidative Stress;  Protein Carbonylation;  Protein Processing, Post-Translational
TODO - Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases. © 2018, Gonos et al.
ER -