TY - JOUR
TI - Sfrp5 associates with beta-cell function in humans
AU - Carstensen-Kirberg, M.
AU - Hatziagelaki, E.
AU - Tsiavou, A.
AU - Chounta, A.
AU - Nowotny, P.
AU - Pacini, G.
AU - Dimitriadis, G.
AU - Roden, M.
AU - Herder, C.
JO - European Journal of Clinical Investigation
PY - 2016
VL - 46
TODO - 6
SP - 535-543
PB - Wiley-Blackwell Publishing Ltd
SN - 0014-2972, 1365-2362
TODO - 10.1111/eci.12629
TODO - C peptide;  glucose;  high density lipoprotein cholesterol;  insulin;  liver enzyme;  low density lipoprotein cholesterol;  secreted frizzled related protein 5;  triacylglycerol;  C peptide;  eye protein;  glucose blood level;  insulin;  membrane protein;  SFRP5 protein, human, Article;  body mass;  cholesterol blood level;  echography;  female;  glucose blood level;  human;  insulin blood level;  insulin sensitivity;  major clinical study;  male;  nonalcoholic fatty liver;  oral glucose tolerance test;  pancreas function;  pancreas islet beta cell;  priority journal;  protein blood level;  triacylglycerol blood level;  adult;  aged;  blood;  complication;  glucose intolerance;  glucose tolerance test;  insulin resistance;  metabolism;  middle aged;  non insulin dependent diabetes mellitus;  obesity;  pancreas islet beta cell;  secretion (process), Adult;  Aged;  Blood Glucose;  C-Peptide;  Diabetes Mellitus, Type 2;  Eye Proteins;  Female;  Glucose Intolerance;  Glucose Tolerance Test;  Humans;  Insulin;  Insulin Resistance;  Insulin-Secreting Cells;  Male;  Membrane Proteins;  Middle Aged;  Non-alcoholic Fatty Liver Disease;  Obesity
TODO - Background: Secreted frizzled-related protein (Sfrp)5 improves insulin sensitivity, but impairs beta-cell function in rodents. However, the relationship between Sfrp5, insulin sensitivity and secretion in humans is currently unclear. Therefore, the aim of the study was to characterize the associations between serum Sfrp5 and indices of insulin sensitivity and beta-cell function from dynamic measurements using oral glucose tolerance tests (OGTT) in humans. Material and methods: This study enrolled 194 individuals with nonalcoholic fatty liver disease (NAFLD), who were diagnosed based on ultrasound and liver transaminases and underwent a frequent sampling 75-g OGTT. Fasting serum Sfrp5 was measured by ELISA. Associations were assessed with several indices of insulin sensitivity and beta-cell function derived from glucose, insulin and C-peptide concentrations during the OGTT. Results: Circulating Sfrp5 associated inversely with the insulinogenic index based on C-peptide (rs = -0·244, P = 0·001), but not with the insulinogenic index based on insulin levels (rs = -0·007, P = 0·926) after adjustment for age, sex and body mass index. Sfrp5 inversely correlated only with QUICKI as a marker of insulin sensitivity in the model adjusted for age and sex (rs = -0·149, P = 0·039). These associations were not influenced by the additional adjustment for hepatic steatosis index. Conclusions: The inverse association of serum Sfrp5 with beta-cell function suggests a detrimental role of Sfrp5 for insulin secretion also in humans. The severity of NAFLD does not appear to affect this relationship. The weak association between serum Sfrp5 and insulin sensitivity was partially explained by body mass. © 2016 Stichting European Society for Clinical Investigation Journal Foundation.
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