TY - JOUR
TI - Update on surgical management of small bowel neuroendocrine tumors
AU - Moris, D.
AU - Ntanasis-Stathopoulos, I.
AU - Tsilimigras, D.I.
AU - Vagios, S.
AU - Karamitros, A.
AU - Karaolanis, G.
AU - Griniatsos, J.
AU - Papalampros, A.
AU - Papaconstantinou, I.
AU - Glantzounis, G.K.
AU - Spartalis, E.
AU - Blazer, D.G.
AU - Felekouras, E.
JO - ANTICANCER RESEARCH
PY - 2018
VL - 38
TODO - 3
SP - 1267-1278
PB - International Institute of Anticancer Research
SN - 0250-1291
TODO - 10.21873/anticanres.12349
TODO - asymptomatic disease;  cancer surgery;  carcinomatous peritonitis;  chemoembolization;  desmoplastic small round cell tumor;  fibrosis;  human;  intestine resection;  liver metastasis;  liver resection;  liver transplantation;  local therapy;  lymph node dissection;  lymph node metastasis;  mesenteric lymph node metastasis;  meta analysis (topic);  multicenter study (topic);  neuroendocrine tumor;  preoperative care;  primary tumor;  priority journal;  radiofrequency ablation;  Review;  small intestine tumor;  surgical technique;  cancer staging;  intestine tumor;  liver tumor;  neuroendocrine tumor;  pathology;  personalized medicine;  postoperative complication;  procedures;  secondary;  small intestine, Hepatectomy;  Humans;  Intestinal Neoplasms;  Intestine, Small;  Liver Neoplasms;  Liver Transplantation;  Neoplasm Staging;  Neuroendocrine Tumors;  Postoperative Complications;  Precision Medicine
TODO - The widespread use of endoscopy and imaging in combination with the continuous update of the staging systems for neuroendocrine tumors has led to an increase in the incidence of small intestinal neuroendocrine tumors (si-NENs) globally. Despite high survival rates, severe complications may occur even in early stages due to the anatomic location of the primary site and the desmoplastic reaction. Surgery plays a central role in the management of patients with si-NENs. Excision of locoregional disease along with extensive lymph node dissection should be performed in fit patients, even in the presence of metastases. Multimodality treatment of liver metastases includes hepatectomy, ablative techniques and liver transplantation. Hormone therapy with somatostatine analogs is of high importance for symptomatic control; special caution should be exercised both pre- and intra-operatively. A multidisciplinary approach is essential in order to provide personalized therapeutics for patients with si-NENs. Clinical research and specialization in this field should be further encouraged. © 2018 International Institute of Anticancer Research. All rights reserved.
ER -