TY - JOUR
TI - Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome
AU - Tsangaris, I.
AU - Tsantes, A.
AU - Vrigkou, E.
AU - Kopterides, P.
AU - Pelekanou, A.
AU - Zerva, K.
AU - Antonakos, G.
AU - Konstantonis, D.
AU - Mavrou, I.
AU - Tsaknis, G.
AU - Kyriazopoulou, E.
AU - Mouktaroudi, M.
AU - Kokori, S.
AU - Orfanos, S.E.
AU - Giamarellos-Bourboulis, E.J.
AU - Armaganidis, A.
JO - Disease Markers
PY - 2017
VL - 2017
TODO - null
SP - null
PB - Hindawi Limited
SN - 0278-0240, 1875-8630
TODO - 10.1155/2017/6758721
TODO - angiopoietin 2;  biological marker;  endocan;  plasminogen activator inhibitor 1;  protein C;  proteoglycan;  unclassified drug;  angiopoietin 2;  biological marker;  C reactive protein;  ESM1 protein, human;  proteoglycan;  tumor protein, adult;  adult respiratory distress syndrome;  Article;  artificial ventilation;  clinical outcome;  cohort analysis;  controlled study;  correlation analysis;  epithelial lining fluid;  female;  Greece;  human;  independent variable;  limit of detection;  logistic regression analysis;  lung alveolus;  lung injury;  lung ventilation;  major clinical study;  male;  middle aged;  mortality;  multiple organ failure;  observational study;  predictive value;  prognosis;  prospective study;  protein blood level;  receiver operating characteristic;  adult respiratory distress syndrome;  aged;  artificial ventilation;  blood;  metabolism, Aged;  Angiopoietin-2;  Biomarkers;  C-Reactive Protein;  Female;  Humans;  Male;  Middle Aged;  Neoplasm Proteins;  Proteoglycans;  Respiration, Artificial;  Respiratory Distress Syndrome, Adult
TODO - Pulmonary endothelium dysfunction is a key characteristic of ARDS. The aim of this study was to investigate endothelium-derived markers, such as angiopoietin-2 (Ang-2) and endothelial cell-specific molecule-1 (endocan), at the vascular and alveolar compartments as outcome predictors in ARDS. Fifty-three consecutive ARDS patients were studied. The primary outcome was 28-day mortality. Secondary endpoints were days of unassisted ventilation and days with organ failure other than ARDS, during the 28-day study period. Nonsurvivors presented higher lung injury scores and epithelial lining fluid (ELF) Ang-2 levels compared to survivors, with no significant differences in plasma Ang-2, endocan, and protein C concentrations between the two groups. In logistic regression analysis, ELF Ang-2 levels > 705 pg/ml were the only independent variable for 28-day mortality among the previous four. Plasma endocan values > 13 ng/pg were the only parameter predictive against days of unassisted ventilation during the 28-day study period. Finally, lung injury score > 2.25 and ELF Ang-2 levels > 705 pg/ml were associated with increased number of days with organ failure, other than ARDS. Our findings suggest that Ang-2 levels are increased in the alveolar compartment of ARDS patients, and this may be associated both with increased mortality and organ failure besides lung. © 2017 Iraklis Tsangaris et al.
ER -