TY - JOUR
TI - Expression and clinical significance of concomitant fak/src and p-paxillin in mobile tongue squamous cell carcinoma
AU - Theocharis, S.
AU - Kotta-Loizou, I.
AU - Giaginis, C.
AU - Alexandrou, P.
AU - Danas, E.
AU - Tsourouflis, G.
AU - Tsoukalas, N.
AU - Coutts, R.H.A.
AU - Tasoulas, J.
AU - Klijanienko, J.
JO - ANTICANCER RESEARCH
PY - 2017
VL - 37
TODO - 3
SP - 1313-1319
PB - International Institute of Anticancer Research
SN - 0250-1291
TODO - 10.21873/anticanres.11449
TODO - focal adhesion kinase;  paxillin;  protein tyrosine kinase;  focal adhesion kinase;  paxillin;  protein tyrosine kinase, adult;  Article;  cancer survival;  controlled study;  disease free survival;  female;  histopathology;  human;  human tissue;  immunohistochemistry;  log rank test;  lymph node metastasis;  male;  middle aged;  priority journal;  proportional hazards model;  protein expression;  protein phosphorylation;  tongue carcinoma;  tumor differentiation;  tumor invasion;  aged;  Carcinoma, Squamous Cell;  cell differentiation;  disease course;  Kaplan Meier method;  metabolism;  pathology;  prognosis;  Tongue Neoplasms;  treatment outcome, Aged;  Carcinoma, Squamous Cell;  Cell Differentiation;  Disease Progression;  Disease-Free Survival;  Female;  Focal Adhesion Protein-Tyrosine Kinases;  Humans;  Immunohistochemistry;  Kaplan-Meier Estimate;  Lymphatic Metastasis;  Male;  Middle Aged;  Paxillin;  Prognosis;  Proportional Hazards Models;  src-Family Kinases;  Tongue Neoplasms;  Treatment Outcome
TODO - Background/Aim: The focal adhesion kinase (FAK)/SRC phosphorylation cascade and its downstream target paxillin have been implicated in malignant transformation, tumor growth and progression, together with metastasis. The present study aimed to evaluate the clinical significance of concomitant FAK/SRC and p-paxillin expression in mobile tongue squamous cell carcinoma (SCC). Materials and Methods: FAK, SRC and phosphopaxillin expression in 48 mobile tongue SCC tissue samples was assessed immunohistochemically and analyzed with respect to clinicopathological characteristics and patient survival. Results: Concomitant high FAK/SRC expression was significantly associated with high grade of tumor differentiation (p=0.048) and longer disease-free patient survival (log-rank test, p=0.019). High p-paxillin expression was significantly associated with greater depth of invasion (p=0.002), lymph node metastasis (p=0.048) and poorer disease-free patient survival (log-rank test, p=0.021; Coxregression analysis, p=0.031). Conclusion: The present study provides evidence that FAK/SRC and paxillin play a role in the pathophysiological aspects of mobile tongue SCC and could constitute therapeutic targets.
ER -