TY - JOUR
TI - The effect of anti-tnf therapy on thyroid function in patients with inflammatory bowel disease
AU - Paschou, S.A.
AU - Palioura, E.
AU - Kothonas, F.
AU - Myroforidis, A.
AU - Loi, V.
AU - Poulou, A.
AU - Goumas, K.
AU - Effraimidis, G.
AU - Vryonidou, A.
JO - Endocrine Journal
PY - 2018
VL - 65
TODO - 11
SP - 1121-1125
PB - Japan Endocrine Society
SN - 0918-8959, 1348-4540
TODO - 10.1507/endocrj.EJ18-0243
TODO - adalimumab;  azathioprine;  infliximab;  mesalazine;  thyroglobulin antibody;  thyroid peroxidase antibody;  thyrotropin;  tumor necrosis factor antibody;  adalimumab;  azathioprine;  gastrointestinal agent;  infliximab;  liothyronine;  mesalazine;  nonsteroid antiinflammatory agent;  thyrotropin;  thyroxine, adult;  antibody detection;  Article;  autoimmunity;  clinical article;  controlled study;  Crohn disease;  drug effect;  female;  free liothyronine index;  free thyroxine index;  human;  inflammatory bowel disease;  male;  outcome assessment;  subclinical hyperthyroidism;  thyroid function;  treatment duration;  ulcerative colitis;  blood;  middle aged;  thyroid function test;  thyroid gland, Adalimumab;  Adult;  Anti-Inflammatory Agents, Non-Steroidal;  Azathioprine;  Female;  Gastrointestinal Agents;  Humans;  Inflammatory Bowel Diseases;  Infliximab;  Male;  Mesalamine;  Middle Aged;  Thyroid Function Tests;  Thyroid Gland;  Thyrotropin;  Thyroxine;  Triiodothyronine
TODO - The aim of this study was to investigate for first time the thyroid function in patients with inflammatory bowel disease (IBD) and the potential effect of anti-TNF (tumor necrosis factor) therapy. We evaluated 41 patients with IBD (25M/ 16F, 36.5 ± 11.3 y, 27 with Crohn’s disease and 14 with ulcerative colitis), without any known thyroid disorder. Eighteen patients (9M/9F, 33.6 ± 8.8 y) were on anti-TNF therapy, while 23 patients (16M/7F, 38.7 ± 12.5 y) were treated with Azathioprine and Mesalazine (Aza/Mes) for more than 1 year. Twelve patients from the second group were then treated with anti-TNF and studied 6 months later. We assessed thyroid function by measuring thyroid stimulating hormone (TSH), free thyroxine (FT4), triiodothyronine (T3), thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) levels. One patient presented with overt and one with subclinical hyperthyroidism. Thyroid auto-antibodies were positive in 12.2%. Patients from the anti-TNF group had lower levels of FT4 (1.09 ± 0.15 vs. 1.38 ± 0.9 ng/dL, p = 0.042), while TSH and T3 were comparable. The percentage of patients with positive thyroid auto-antibodies was lower in the anti-TNF group (5.6% vs. 17.4%). In the subgroup of patients who changed to anti-TNF, we found statistically significant reduction in FT4 after 6 months (1.26 ± 0.24 vs. 1.08 ± 0.15 ng/dL, p = 0.044), without changes in TSH and T3 levels. There was no change regarding thyroid auto-antibodies. In conclusion, patients with IBD showed a quite high percentage of thyroid autoimmunity. After treatment with anti-TNF, FT4 levels were found to be reduced, while no changes in TSH, T3 levels and thyroid auto-antibodies were noted. ©The Japan Endocrine Society.
ER -