TY - JOUR
TI - Atypical femoral fractures (AFF) from bone remodeling agents in patients with cancer
AU - Kordoni, M.
AU - Rigakos, G.
AU - Kim, Y.H.M.
AU - Kaklamanis, L.
AU - Nikolatou-Galitis, O.
AU - Hadjiyassemi, L.
AU - Labropoulos, S.
AU - Razis, E.
JO - ANTICANCER RESEARCH
PY - 2018
VL - 38
TODO - 11
SP - 6439-6444
PB - International Institute of Anticancer Research
SN - 0250-1291
TODO - 10.21873/anticanres.13005
TODO - bisphosphonic acid derivative;  capecitabine;  carboplatin;  cyclophosphamide;  denosumab;  docetaxel;  doxorubicin;  epidermal growth factor receptor 2;  epirubicin;  eribulin;  fluorouracil;  gemcitabine;  lapatinib;  methotrexate;  nabpaclitaxel;  paclitaxel;  pertuzumab;  trastuzumab;  trastuzumab emtansine;  unclassified drug;  vinorelbine tartrate;  zoledronic acid;  bisphosphonic acid derivative;  bone density conservation agent;  denosumab, add on therapy;  adjuvant chemotherapy;  adult;  aged;  Article;  atypical femoral fracture;  atypical femoral fractures;  axillary lymph node;  bone biopsy;  bone lesion;  bone metastasis;  bone remodeling;  breast cancer;  cancer chemotherapy;  cancer patient;  cancer recurrence;  cancer staging;  carcinomatous meningitis;  case report;  clinical article;  disease exacerbation;  drug substitution;  drug withdrawal;  electromyography;  female;  femoral neck;  femoral neck fracture;  femur;  femur diaphysis;  femur fracture;  gene overexpression;  hip pain;  hip replacement;  histology;  human;  human epidermal growth factor receptor 2 positive breast cancer;  intramedullary nailing;  jaw osteonecrosis;  lower limb;  lumbar spine;  lymph node;  maintenance therapy;  metastatic breast cancer;  middle aged;  modified radical mastectomy;  multiple cycle treatment;  nuclear magnetic resonance imaging;  osteoporosis;  partial mastectomy;  periosteum;  positron emission tomography-computed tomography;  priority journal;  quality of life;  radiosurgery;  supraclavicular lymph node;  treatment response;  walking difficulty;  weight bearing;  X ray;  x-ray computed tomography;  breast tumor;  chemically induced;  complication;  diagnostic imaging;  femur fracture;  radiography, Aged;  Bone Density Conservation Agents;  Breast Neoplasms;  Denosumab;  Diphosphonates;  Female;  Femoral Fractures;  Humans;  Middle Aged;  Quality of Life;  Radiography
TODO - Anti-resorptive drugs like bisphosphonates (BP) and denosumab are widely used for prevention and treatment of skeletal diseases, such as osteoporosis and bone metastases and mainly work through the prevention of osteoclast-mediated bones resorption. BP can lead to atypical femoral fractures (AFF) that is a rare, easily misdiagnosed treatment-related complication with great impact on the quality of life of patients. We present a concise review of the literature on BP related AFF based on the cases of 3 breast cancer patients that reflect the diagnostic pitfall of this rare entity. In conclusion, breast cancer patients very often are exposed to BP use and are at risk of developing AFF. © 2018 International Institute of Anticancer Research.All right reserved.
ER -