TY - JOUR
TI - CORL expression and function in insulin producing neurons reversibly influences adult longevity in Drosophila
AU - Tran, N.L.
AU - Goldsmith, S.L.
AU - Dimitriadou, A.
AU - Takaesu, N.T.
AU - Consoulas, C.
AU - Newfeld, S.J.
JO - G3: Genes, Genomes, Genetics
PY - 2018
VL - 8
TODO - 9
SP - 2979-2990
PB - Genetics Society of America
SN - 2160-1836
TODO - 10.1534/g3.118.200572
TODO - corl protein;  genomic DNA;  insect protein;  insulin;  unclassified drug;  Drosophila protein;  insulin, adult;  Article;  brain nerve cell;  controlled study;  corl reporter gene;  Drosophila;  female;  insulin signaling;  larva;  lifespan;  longevity;  male;  mating;  nonhuman;  null allele;  protein function;  reporter gene;  animal;  biosynthesis;  cytology;  Drosophila melanogaster;  gene expression regulation;  longevity;  metabolism;  nerve cell;  nerve cell network;  neurosecretion;  physiology, Animals;  Drosophila melanogaster;  Drosophila Proteins;  Female;  Gene Expression Regulation;  Insulin;  Longevity;  Male;  Nerve Net;  Neurons;  Neurosecretion
TODO - CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals. © 2018 Tran et al.
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