TY - JOUR
TI - Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer
AU - Childs, E.J.
AU - Mocci, E.
AU - Campa, D.
AU - Bracci, P.M.
AU - Gallinger, S.
AU - Goggins, M.
AU - Li, D.
AU - Neale, R.E.
AU - Olson, S.H.
AU - Scelo, G.
AU - Amundadottir, L.T.
AU - Bamlet, W.R.
AU - Bijlsma, M.F.
AU - Blackford, A.
AU - Borges, M.
AU - Brennan, P.
AU - Brenner, H.
AU - Bueno-De-Mesquita, H.B.
AU - Canzian, F.
AU - Capurso, G.
AU - Cavestro, G.M.
AU - Chaffee, K.G.
AU - Chanock, S.J.
AU - Cleary, S.P.
AU - Cotterchio, M.
AU - Foretova, L.
AU - Fuchs, C.
AU - Funel, N.
AU - Gazouli, M.
AU - Hassan, M.
AU - Herman, J.M.
AU - Holcatova, I.
AU - Holly, E.A.
AU - Hoover, R.N.
AU - Hung, R.J.
AU - Janout, V.
AU - Key, T.J.
AU - Kupcinskas, J.
AU - Kurtz, R.C.
AU - Landi, S.
AU - Lu, L.
AU - Malecka-Panas, E.
AU - Mambrini, A.
AU - Mohelnikova-Duchonova, B.
AU - Neoptolemos, J.P.
AU - Oberg, A.L.
AU - Orlow, I.
AU - Pasquali, C.
AU - Pezzilli, R.
AU - Rizzato, C.
AU - Saldia, A.
AU - Scarpa, A.
AU - Stolzenberg-Solomon, R.Z.
AU - Strobel, O.
AU - Tavano, F.
AU - Vashist, Y.K.
AU - Vodicka, P.
AU - Wolpin, B.M.
AU - Yu, H.
AU - Petersen, G.M.
AU - Risch, H.A.
AU - Klein, A.P.
JO - Nature Genetics
PY - 2015
VL - 47
TODO - 8
SP - 911-916
PB - Nature Publishing Group
SN - 1061-4036, 1546-1718
TODO - 10.1038/ng.3341
TODO - E1A associated p300 protein;  hepatocyte nuclear factor 1;  hepatocyte nuclear factor 3alpha;  hepatocyte nuclear factor 3beta;  protein;  RAD21 protein;  unclassified drug, Article;  cancer risk;  controlled study;  gene linkage disequilibrium;  gene locus;  genetic association;  genetic susceptibility;  genetic variability;  genotype;  human;  major clinical study;  pancreas adenocarcinoma;  pancreas cancer;  phenotype;  phenotypic variation;  priority journal;  quantitative trait locus;  single nucleotide polymorphism;  smoking;  tissues;  aged;  Australia;  chromosome 17;  chromosome 2;  chromosome 3;  chromosome 7;  clinical trial;  Europe;  female;  gene frequency;  genetic predisposition;  genetics;  male;  middle aged;  multicenter study;  North America;  pancreas tumor;  procedures;  risk factor;  single nucleotide polymorphism, Aged;  Australia;  Chromosomes, Human, Pair 17;  Chromosomes, Human, Pair 2;  Chromosomes, Human, Pair 3;  Chromosomes, Human, Pair 7;  Europe;  Female;  Gene Frequency;  Genetic Loci;  Genetic Predisposition to Disease;  Genome-Wide Association Study;  Genotype;  Humans;  Male;  Middle Aged;  North America;  Pancreatic Neoplasms;  Polymorphism, Single Nucleotide;  Risk Factors
TODO - Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10-14), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10-8) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10-8). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10-9), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk. © 2015 Nature America, Inc. All rights reserved.
ER -