TY - JOUR
TI - Can anti-Mullerian hormone (AMH) predict the outcome of intrauterine insemination with controlled ovarian stimulation?
AU - Bakas, P.
AU - Boutas, I.
AU - Creatsa, M.
AU - Vlahos, N.
AU - Gregoriou, O.
AU - Creatsas, G.
AU - Hassiakos, D.
JO - Gynecological Endocrinology
PY - 2015
VL - 31
TODO - 10
SP - 765-768
PB - Taylor and Francis Ltd.
SN - 0951-3590, 1473-0766
TODO - 10.3109/09513590.2015.1025381
TODO - luteinizing hormone;  Muellerian inhibiting factor;  recombinant follitropin;  estradiol;  follitropin;  luteinizing hormone;  Muellerian inhibiting factor, adult;  age;  Article;  controlled ovarian stimulation;  female;  hormone blood level;  human;  infertility therapy;  intrauterine insemination;  major clinical study;  predictive value;  pregnancy;  pregnancy rate;  priority journal;  artificial insemination;  blood;  Infertility, Female;  ovulation induction;  pregnancy;  treatment outcome, Adult;  Anti-Mullerian Hormone;  Estradiol;  Female;  Follicle Stimulating Hormone;  Humans;  Infertility, Female;  Insemination, Artificial;  Luteinizing Hormone;  Ovulation Induction;  Pregnancy;  Pregnancy Rate;  Treatment Outcome
TODO - Objective: To assess whether the levels of anti-Mullerian hormone (AMH) are related to outcome of intrauterine insemination (IUI) in patients treated with gonadotropins.Intervention(s): A total of 195 patients underwent controlled ovarian stimulation (COS) with recombinant follicle stimulating hormone (rFSH) (50-150 IU/d). All patients were submitted upto three cycles of IUI.Outcome: Primary outcome was the ability of AMH levels to predict clinical pregnancy at first attempt and the cumulative clinical pregnancy probability of upto three IUI cycles. Secondary outcomes were the relation of AMH, LH, FSH, BMI, age, parity and basic estradiol levels with each other and the outcome of IUI.Results: The area under the receiver operating characteristic (ROC) curve in predicting clinical pregnancy for AMH at first attempt was 0.53 and for cumulative clinical pregnancy was 0.76. AMH levels were positively correlated with clinical pregnancy rate at first attempt and with cumulative clinical pregnancy rate, but negatively correlated with patients age and FSH levels. Patients FSH, LH levels were negatively correlated with cumulative clinical pregnancy rate.Conclusions: AMH levels seem to have a positive correlation and patients age and LH levels had a negative correlation with the outcome of IUI and COS with gonadotropins. AMH concentration was significantly higher and LH was significantly lower in patients with a clinical pregnancy after three cycles of IUI treatment compared with those who did not achieve pregnancy. © 2015 Taylor & Francis.
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