TY - JOUR
TI - Are patients with autoimmune thyroid disease and autoimmune gastritis at risk of gastric neuroendocrine neoplasms type 1?
AU - Alexandraki, K.I.
AU - Nikolaou, A.
AU - Thomas, D.
AU - Syriou, V.
AU - Korkolopoulou, P.
AU - Sougioultzis, S.
AU - Kaltsas, G.
JO - Clinical Endocrinology
PY - 2014
VL - 80
TODO - 5
SP - 685-690
PB - Wiley-Blackwell Publishing Ltd
SN - 0300-0664, 1365-2265
TODO - 10.1111/cen.12346
TODO - chromogranin A;  gastrin;  parietal cell antibody;  chromogranin A;  gastrin, adult;  article;  autoimmune disease;  autoimmune gastritis;  cancer risk;  cell hyperplasia;  clinical assessment;  controlled study;  disease association;  enterochromaffin like cell hyperplasia;  female;  gastric neuroendocrine tumor type 1;  gastrin blood level;  gastritis;  gastroenteropancreatic neuroendocrine tumor;  gastrointestinal endoscopy;  Graves disease;  Hashimoto disease;  human;  human tissue;  major clinical study;  male;  nodular hyperplasia;  observational study;  patient assessment;  priority journal;  prospective study;  protein blood level;  stomach biopsy;  stomach mucosa;  upper gastrointestinal tract endoscopy;  aged;  Autoimmune Diseases;  blood;  complication;  cytology;  endoscopy;  enterochromaffin like cell;  gastritis;  genetics;  Hashimoto disease;  Helicobacter infection;  middle aged;  Neuroendocrine Tumors;  phenotype;  prevalence;  risk;  stomach tumor;  Thyroid Diseases, Aged;  Autoimmune Diseases;  Chromogranin A;  Endoscopy;  Enterochromaffin-like Cells;  Female;  Gastrins;  Gastritis;  Hashimoto Disease;  Helicobacter Infections;  Humans;  Male;  Middle Aged;  Neuroendocrine Tumors;  Phenotype;  Prevalence;  Prospective Studies;  Risk;  Stomach Neoplasms;  Thyroid Diseases
TODO - Objective The aim of this study was to investigate the prevalence of autoimmune gastritis, enterochromaffin-like cell (ECL-cell) hyperplasia and gastric neuroendocrine neoplasms type 1 (GNEN1) in patients with autoimmune thyroid disease. Design Prospective observational study in a single institutional study. Patients and Measurements One hundred and twenty patients with autoimmune thyroid disease were consecutively recruited from the Endocrine Unit. Upper gastrointestinal tract endoscopy (UGE) and biochemical parameters for autoimmune thyroid disease and autoimmune gastritis were assessed at recruitment and annually thereafter in patients with a mean follow-up of 37.5 ± 14.4 months. Autoimmune gastritis was defined by the presence of antiparietal cell antibodies (APCA) and histological confirmation after UGE. Serum gastrin and chromogranin I were also measured. Results One hundred and eleven patients had Hashimoto's thyroiditis and nine Graves' disease. Autoimmune gastritis was identified in 40 (38 with Hashimoto's thyroiditis and two with Graves' disease) patients all of whom had increased levels of gastrin and chromogranin I; Helicobacter pylori infection was histologically identified in 15 of 40 (37.5%) patients. Six patients had isolated nodular ECL-cell hyperplasia and one mixed nodular and linear ECL-cell hyperplasia [7 of 40 (17.5%)]. Only increased gastrin (P = 0.03) levels predicted the presence ECL-cell hyperplasia. A GNEN1 developed in one patient with nodular ECL-cell hyperplasia after 39 months of follow-up. Conclusions Concomitant autoimmune gastritis was found in 33.3% of patients with autoimmune thyroid disease, 17.5% of whom had ECL-cell hyperplasia that evolved to GNEN1 in one (2.5%). Larger studies with longer follow-up are needed to define the incidence of GNEN1 in patients with autoimmune thyroid disease and ECL-cell hyperplasia and potential implications. © 2013 John Wiley & Sons Ltd.
ER -