TY - JOUR
TI - Insulin resistance and cardiometabolic risk factors in obese children and adolescents: A hierarchical approach
AU - Sakou, I.-I.
AU - Psaltopoulou, T.
AU - Sergentanis, T.N.
AU - Karavanaki, K.
AU - Karachaliou, F.
AU - Ntanasis-Stathopoulos, I.
AU - Tzanninis, S.
AU - Sdogou, T.
AU - Greydanus, D.
AU - Tsitsika, A.
JO - Journal of Pediatric Endocrinology and Metabolism
PY - 2015
VL - 28
TODO - 5-6
SP - 589-596
PB - Walter de Gruyter GmbH
SN - null
TODO - 10.1515/jpem-2014-0431
TODO - high density lipoprotein;  insulin, adolescent;  adult;  anthropometric parameters;  Article;  body mass;  cardiometabolic risk;  child;  childhood obesity;  clinical evaluation;  dyslipidemia;  female;  human;  hypertension;  hypertriglyceridemia;  insulin resistance;  major clinical study;  male;  risk assessment;  weight reduction;  complication;  Dyslipidemias;  hypertension;  metabolism;  obesity;  pathophysiology;  risk factor;  young adult, Adolescent;  Adult;  Child;  Dyslipidemias;  Female;  Humans;  Hypertension;  Insulin Resistance;  Male;  Obesity;  Risk Factors;  Young Adult
TODO - Background: This study aims to globally assess the network of insulin resistance (IR)-related factors in a sample of overweight and obese Greek youths. Methods: A total of 185 subjects were examined, and IR was quantified by homeostasis model assessment (HOMA-IR). Multivariate hierarchical approach was performed, and five distinct levels were recognized, namely, immutable demographic features and early life parameters, current anthropometric measures, IR, unfavorable clinical conditions, and social parameters. Two analyses were performed based on HOMA-IR cut-off values (3.16 and, as an alternative, 3.99). Results: Obesity was associated with IR (adjusted OR=3.19, 95% CI: 1.12-9.09). IR steadily predicted low HDL (adjusted OR=5.75, 95% CI: 1.58-20.87), hypertriglyceridemia (adjusted OR=10.28, 95% CI: 1.18-89.55), and systolic hypertension. At the alternative analysis, IR was also associated with older age, older age at menarche, hyperuricemia, and low school grades. Conclusion: Emerging on the grounds of obesity, IR confers risks for dyslipidemia and hypertension at a relatively early age. Along with weight loss, interventions targeted at IR are required to prevent cardiometabolic risk in adolescence. © 2015 by De Gruyter.
ER -