TY - JOUR
TI - Ischemia modified albumin, high-sensitivity c-reactive protein and natriuretic peptide in patients with coronary atherosclerosis
AU - Kazanis, K.
AU - Dalamaga, M.
AU - Nounopoulos, C.
AU - Manolis, A.S.
AU - Sakellaris, N.
AU - Jullien, G.
AU - Dionyssiou-Asteriou, A.
JO - Clinica Chimica Acta
PY - 2009
VL - 408
TODO - 1-2
SP - 65-69
PB - 
SN - 0009-8981
TODO - 10.1016/j.cca.2009.07.007
TODO - antioxidant;  brain natriuretic peptide;  C reactive protein;  ischemia modified albumin, acute coronary syndrome;  adult;  age distribution;  aged;  angiocardiography;  article;  cardiovascular risk;  controlled study;  coronary artery atherosclerosis;  coronary artery disease;  correlation function;  early diagnosis;  female;  human;  major clinical study;  male;  medical documentation;  priority journal;  sensitivity and specificity;  sex difference, Adult;  Aged;  Aged, 80 and over;  Antioxidants;  Biological Markers;  C-Reactive Protein;  Case-Control Studies;  Coronary Angiography;  Coronary Artery Disease;  Female;  Humans;  Male;  Middle Aged;  Natriuretic Peptides;  Necrosis;  Serum Albumin;  Troponin T
TODO - Background: Ischemia modified albumin (IMA), is a new biomarker of oxidative processes involved with coronary artery disease (CAD). We determined serum IMA, high-sensitivity C-reactive protein (hsCRP), and natriuretic peptide (NT-proBNP), and evaluated their correlation with severity of coronary atherosclerosis in patients undergoing coronary angiography (CA). Cardiac troponin T (cTnT), CK-MB mass, albumin and Total Antioxidant Status (TAS) were also evaluated. Methods: The study included 114 patients (88 men and 30 women) aged 43-80 years with documented CAD without evidence of acute coronary syndrome undergoing CA and 163 controls (131 men and 32 women) similarly aged. Results: IMA, hsCRP and NT-proBNP were higher (p < 0.001 and p = 0.008 for NT-proBNP) while TAS was lower (p < 0.001) in patients than in controls. IMA and TAS were negatively correlated in all subjects (p < 0.01). Among patients, there was no correlation between IMA and the number of diseased vessels. For CAD diagnosis the best cut-off point for IMA was 101.5 KU/L with a sensitivity and a specificity of 87.7% and a negative predictive value of 83.3%. IMA was associated with an increased risk for CAD (OR = 1.23, 95% CI: 1.16-1.31; p < 0.001). Conclusions: IMA determination may provide earlier information of CAD presence before hsCRP or NT-proBNP elevation, contributing to early assessment of overall patient risk. © 2009 Elsevier B.V. All rights reserved.
ER -