TY - JOUR
TI - Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer
AU - Petraki, C.
AU - Dubinski, W.
AU - Scorilas, A.
AU - Saleh, C.
AU - Pasic, M.D.
AU - Komborozos, V.
AU - Khalil, B.
AU - Gabril, M.Y.
AU - Streutker, C.
AU - Diamandis, E.P.
AU - Yousef, G.M.
JO - PATHOLOGY RESEARCH AND PRACTICE
PY - 2012
VL - 208
TODO - 2
SP - 104-108
PB - 
SN - 0344-0338
TODO - 10.1016/j.prp.2011.12.010
TODO - kallikrein 6, adult;  aged;  article;  cancer staging;  clinical feature;  colon mucosa;  colorectal cancer;  controlled study;  correlation analysis;  disease course;  disease free survival;  female;  histopathology;  human;  human tissue;  immunohistochemistry;  liver metastasis;  lymph node metastasis;  major clinical study;  male;  overall survival;  prediction;  prognosis;  protein expression;  scoring system, Adult;  Aged;  Aged, 80 and over;  Carcinoma;  Chi-Square Distribution;  Colorectal Neoplasms;  Disease-Free Survival;  Female;  Greece;  Humans;  Immunohistochemistry;  Kallikreins;  Kaplan-Meier Estimate;  Liver Neoplasms;  Lymphatic Metastasis;  Male;  Middle Aged;  Neoplasm Staging;  Prognosis;  Proportional Hazards Models;  Risk Assessment;  Risk Factors;  Time Factors;  Tumor Markers, Biological
TODO - The prognosis of patients with colorectal cancer (CRC) is assessed through conventional clinicopathological parameters, which are not always accurate. Members of the human kallikrein-related peptidases gene family represent potential cancer biomarkers. The aim of this study was to investigate the expression of human tissue kallikrein-related peptidase 6 (KLK6) by immunohistochemistry in CRC to correlate this expression with various histopathological and clinical variables, and to evaluate its significance as a predictor of disease outcome. KLK6 expression was evaluated by immunohistochemistry and an expression score was calculated for each case. In CRC, KLK6 expression was decreased compared to normal colonic mucosa. A statistically significant, positive association was observed between KLK6 and tumor stage (p=0.036), lymph node metastases (p=0.030), and liver metastases (p=0.025). Univariate analysis showed that KLK6 expression and stage had statistically significant correlation with disease-free survival (p=0.045 and p<0.001, respectively) and overall survival (p=0.027 and p<0.001, respectively). Cox multivariate analysis showed that KLK6 expression was an independent predictor of unfavorable overall survival (p=0.041). Kaplan-Meier survival curves showed that KLK6-positive patients have statistically significant lower disease-free and overall survival. In conclusion, KLK6 immunostaining is an independent prognostic marker in patients with CRC. © 2012 Elsevier GmbH.
ER -