TY - JOUR
TI - Vascular endothelial growth factor and endoglin expression in colorectal cancer
AU - Dassoulas, K.
AU - Gazouli, M.
AU - Theodoropoulos, G.
AU - Christoni, Z.
AU - Rizos, S.
AU - Zisi-Serbetzoglou, A.
AU - Glava, C.
AU - Karantanos, T.
AU - Klonaris, C.
AU - Karakitsos, P.
JO - Journal of Cancer Research and Clinical Oncology
PY - 2010
VL - 136
TODO - 5
SP - 703-708
PB - 
SN - 0171-5216, 1432-1335
TODO - 10.1007/s00432-009-0709-y
TODO - endoglin;  vasculotropin;  cell surface receptor;  ENG protein, human;  leukocyte antigen;  vasculotropin A, adult;  aged;  article;  clinical feature;  colorectal cancer;  controlled study;  correlation analysis;  disease association;  female;  histopathology;  human;  human tissue;  immunohistochemistry;  Kaplan Meier method;  major clinical study;  male;  overall survival;  priority journal;  prognosis;  protein expression;  colorectal tumor;  metabolism;  middle aged;  mortality;  pathology, Adult;  Aged;  Aged, 80 and over;  Antigens, CD;  Colorectal Neoplasms;  Female;  Humans;  Male;  Middle Aged;  Prognosis;  Receptors, Cell Surface;  Vascular Endothelial Growth Factor A
TODO - Purpose and methods: Vascular endothelial growth factor (VEGF) overexpression has been associated with advanced stage and poor survival in several cancers. Additionally, endoglin was proposed as a marker of neovascularization in solid malignancies. The aim of this study was to evaluate the association between the VEGF and endoglin expression in colorectal carcinoma patients, as well as to correlate the VEGF and endoglin expression with standard parameters, to deWne their potential prognostic role. VEGF and endoglin expression were evaluated in 99 unrelated patients with colorectal cancer using immunohistochemistry. Results: Vascular endothelial growth factor and endoglobin expression were positively interrelated. No signiWcant correlation of VEGF and endoglin expression with clinicopathological parameters was observed in our cases. The Kaplan-Meier survival curves have demonstrated a clear association of cancer-speciWc overall survival with high VEGF, as well as high endoglin expression. Conclusion: Our results support that VEGF and endoglin act as two valuable indicators of prognosis.
ER -