TY - JOUR
TI - Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia
AU - Braoudaki, M.
AU - Katsibardi, K.
AU - Giudicelli, V.
AU - Karamolegou, K.
AU - Papathanassiou, C.
AU - Lefranc, M.-P.
AU - Tzortzatou-Stathopoulou, F.
JO - Cancer Investigation
PY - 2011
VL - 29
TODO - 5
SP - 360-364
PB - 
SN - 0735-7907, 1532-4192
TODO - 10.3109/07357907.2011.584587
TODO - acute lymphoblastic leukemia;  article;  cancer diagnosis;  cancer relapse;  childhood disease;  controlled study;  gene frequency;  gene rearrangement;  gene sequence;  human;  human tissue;  immunoglobulin gene;  major clinical study;  mutational analysis;  priority journal;  sequence analysis;  somatic hypermutation, Biopsy;  Bone Marrow Examination;  DNA Mutational Analysis;  Gene Rearrangement, B-Lymphocyte;  Genes, Immunoglobulin;  Greece;  Humans;  Immunoglobulin Variable Region;  Precursor Cell Lymphoblastic Leukemia-Lymphoma;  Recurrence;  Somatic Hypermutation, Immunoglobulin
TODO - The current study investigated the presence, frequency, and status of somatic hypermutations as well as their role in children with B lineage ALL. The obtained sequences were analyzed using IMGT/V-QUEST. Totally, 150 IGH sequences were evaluated; 139 from the 111 patients at the time of diagnosis and 11 from 8/111 patients at the time of relapse. The findings of the current report revealed the presence of somatically mutated V genes in childhood B lineage ALL. A higher frequency of somatic hypermutations was noted in unproductive rearrangements and was generally attributed to nucleotide mutation type, region, and IGHV gene subgroup biases. © 2011 Informa Healthcare USA, Inc.
ER -