TY - JOUR
TI - Serum cytokine concentrations in alcohol-dependent individuals without
liver disease
AU - Nicolaou, C
AU - Chatzipanagiotou, S
AU - Tzivos, D
AU - Tzavellas, EO and
AU - Boufidou, F
AU - Liappas, IA
JO - Alcohol
PY - 2004
VL - 32
TODO - 3
SP - 243-247
PB - EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
SN - 0741-8329
TODO - 10.1016/j.alcohol.2004.02.004
TODO - cytokines; alcohol; liver disease; interleukin 6; IL-6
TODO - In the current study, our aim was to evaluate and investigate the
influence of heavy alcohol intake on serum interleukin (IL)-6, IL-8,
IL-10, IL-12, and tumor necrosis factor-alpha (TNF-alpha)
concentrations. The selection of cytokines was based on their
presumptive role in the pathophysiology of alcohol dependence. On
admission to the Drug-Free Substance Addiction Detoxification clinic
(”ATHENA”), blood samples were obtained from study participants,
and serum cytokine concentrations were measured by using a commercial
sandwich enzyme-linked immunosorbent assay technique. Alcohol
dependence, as diagnosed according to DSM-IV [Diagnostic and
Statistical Manual of Mental Disorders (4th ed.)] criteria for alcohol
dependence and estimated by using the Composite International Diagnostic
Interview (CIDI), was characterized by increased serum IL-6
concentration. Interleukin-8, IL-10, IL-12, and TNF-alpha concentrations
were comparable to those found in control subjects (P > .05). These
results indicate that in alcohol-dependent individuals there is a
significant increase in the serum IL-6 concentration (P < .05). (C) 2004
Elsevier Inc. All rights reserved.
ER -