TY - JOUR
TI - A bioresorbable calcium phosphate delivery system with teicoplanin for
treating MRSA osteomyelitis
AU - Lazarettos, J
AU - Efstathopoulos, N
AU - Papagelopoulos, PJ
AU - Savvidou,
AU - A
AU - Kanellakopoulou, K
AU - Giamarellou, H
AU - Giamarellos-Bourboulis,
AU - EJ
AU - Nikolaou, V
AU - Kapranou, A
AU - Papalois, A
AU - Papachristou, G
JO - Clinical Orthopaedics and Related Research
PY - 2004
VL - null
TODO - 423
SP - 253-258
PB - Lippincott, Williams & Wilkins
SN - 0009-921X, 1528-1132
TODO - 10.1097/01.blo.0000127422.06956.35
TODO - null
TODO - To assess the effectiveness of calcium phosphate as a delivery system of
teicoplanin, methicillin-resistant Staphylococcus aureus osteomyelitis
was induced in 36 rabbits. Osteomyelitis was induced by inoculating
10(7) cfu of methicillin-resistant Staphylococcus aureus isolate into a
2-mm hole at the upper 1/3 of the femur for 3 weeks, when all animals
had reoperations, and calcium phosphate cement with 3% teicoplanin was
implanted. Animals were divided into six groups of six animals each,
sacrificed at Weeks 1, 2, 3, 4, 5, and 6, respectively, after
implantation. One rabbit in each group was used as a control.
Substantial clinical improvement of the rabbits was observed after
implantation, accompanied with sterile cultures of bone after the second
week of treatment. Throughout the same period, 10(5) to 10(8) cfu/g of
methicillin-resistant Staphylococcus aureus isolate was cultured from
the control samples. Bacterial eradication signified a considerable
decrease of the total histologic scores of osteomyelitis compared with
controls, accompanied with newly growing host bone. The calcium
phosphate with teicoplanin delivery system seems promising for treatment
of bone infection attributable to methicillin-resistant Staphylococcus
aureus. In addition, this mixture allows filling of bone defects by new
host bone.
ER -