TY - JOUR
TI - Levels of soluble forms of ICAM and VCAM in patients with
myelodysplastic syndromes and their prognostic significance
AU - Passam, FH
AU - Tsirakis, G
AU - Boula, A
AU - Fragou, A
AU - Consolas, I
AU - and Alegakis, A
AU - Kyriakou, DS
AU - Alexandrakis, MG
JO - CLINICAL AND LABORATORY HAEMATOLOGY
PY - 2004
VL - 26
TODO - 6
SP - 391-395
PB - Wiley
SN - null
TODO - 10.1111/j.1365-2257.2004.00640.x
TODO - cell adhesion molecules; myelodysplastic syndrome; IL-1 beta; sICAM;
sVCAM
TODO - The aim of this study was to assess circulating soluble intercellular
adhesion molecule-1 (sICAM-1). soluble vascular cell adhesion molecule-1
(sVCAM-1). and interleukin-1beta (IL-1beta) in myelodysplastic syndromes
(MDS) in order to evaluate their clinical significance. Seventy patients
with untreated NOS [21 refractory anemia (RA), nine RA with ringed
sideroblasts (RARS). 17 RA with excess of blasts (R-AM). 11 RAEB in
transformation (RAEBt). and 12 chronic myelomonocytic leukemia (CMML)]
were included in this study, Serum levels of sICAM, sVCAM, and IL-1beta
were determined at diagnosis using commercially available immunoassays.
In addition. 15 healthy, volunteers were studied as a control group.
sICAM, sVCAM, and Il-1beta serum levels were significantly higher in MDS
patients in comparison with the control group (P < 0.001). Patients with
CMML showed the highest sICAM. sVCAM. and IL-1beta levels in comparison
with other MDS-related subtypes. Furthermore significantly elevated
levels of the studied parameters were detected in high-risk MDS patients
(RAEB, RAEB-t, and CMML) in comparison with low-risk MDS (RA and RARS).
IL-1beta was strongly correlated both to sICAM and sVCAM. In conclusion
we have provided evidence that increased sICAM and sVCAM serum levels
are related to MDS severity.
ER -