TY - JOUR
TI - The impact of deep sternal wound infection on long-term survival after
coronary artery bypass grafting
AU - Toumpoulis, IK
AU - Anagnostopoulos, CE
AU - DeRose, JJ
AU - Swistel, DG
JO - Chest
PY - 2005
VL - 127
TODO - 2
SP - 464-471
PB - Elsevier
SN - 0012-3692, 1931-3543
TODO - 10.1378/chest.127.2.464
TODO - coronary artery bypass grafting; deep sternal wound infection; long-term
mortality; risk factors
TODO - Objectives: To identify the impact of deep sternal wound infection
(DSWI) on long-term survival after coronary artery bypass grafting
(CABG).
Background: DSWI following CABG is an infrequent, yet devastating
complication with increased morbidity and mortality. However, little has
been published regarding the impact of DSWI on long-term mortality.
Methods: We studied 3,760 consecutive patients who underwent isolated
CABG between 1992 and 2002. Patients with CABG and no DSWI were compared
with those in whom DSWI developed. Long-term survival data (mean
follow-up, 5.2 years) were obtained from the National Death Index.
Groups were compared by Cox proportional hazard models and Kaplan-Meier
survival plots. The propensity for DSWI was determined by logistic
regression analysis, and each patient with DSWI was then matched to 10
patients without DSWI.
Results: DSWI developed in 40 of 3,760 patients (1.1%). Independent
predictors for DSWI were diabetes (odds ratio [OR], 5.5; 95%
confidence interval [CI], 2.7 to 11.6; p < 0.001), hemodynamic
instability preoperatively (OR, 4.0; 95% CI, 1.2 to 13.9; p = 0.026),
preoperative renal failure on dialysis (OR, 3.4; 95% CI, 1.0 to 13.6; p
= 0.049), use of bilateral internal thoracic arteries (OR, 2.6; 95% CI,
1.3 to 5.3; p = 0.010), and sepsis and/or endocarditis after CABG (OR,
29.9; 95% CI, 11.7 to 76.4; p < 0.001). Patients with DSWI had
prolonged length of stay (35.0 days vs; 16.4 days; p < 0.001); however,
there was no difference in early mortality between matched groups. After
adjustment for preoperative, intraoperative, and postoperative factors,
the adjusted hazard ratio of long-term mortality for patients with DSWI
was 2.44 (95% CI, 1.51 to 3.92; p < 0.001). Patients without DSWI had a
better 5-year survival rate (72.8 +/- 2.4% vs 50.8.6 +/- 8.5% [mean
SE]; p = 0.0007 between matched groups).
Conclusions: We found that DSWI following CABG was associated with
increased long-term mortality during a 10-year follow-up study.
ER -