TY - JOUR
TI - Mechanisms of ketamine action on lipid metabolism in rats
AU - Saranteas, T
AU - Zotos, N
AU - Lolis, E
AU - Stranomiti, J
AU - Mourouzis,
AU - C
AU - Chantzi, C
AU - Tesseromatis, C
JO - European Journal of Anaesthesiology
PY - 2005
VL - 22
TODO - 3
SP - 222-226
PB - Lippincott, Williams & Wilkins
SN - 0265-0215, 1365-2346
TODO - 10.1017/S0265021505000384
TODO - anaesthetic agents; ketamine; lipids; lipoprotein lipase
TODO - Background and objective: This study was conducted to determine the
effect of ketamine on metabolic homoeostasis and particularly in
lipoprotein lipase (LPL) activity in adipose tissue.
Methods: Sixty male Wistar rats were divided into six groups of 10 each.
Group A served as controls, while Groups B-F received, respectively,
ketamine 60, 80, 100, 120 and 140 mg kg(-1) intraperitoneally. The
animals were sacrificed 20 min after the administration of ketamine.
Insulin concentrations in plasma and total cholesterol, triglyceride,
high-density lipoprotein (HDL) and free fatty acid (FFA) concentrations
in serum were measured. LPL activity in adipose tissue and medium-chain
acyl-CoA dehydrogenase (MCAD) content in muscle were determined.
Results: FFA concentrations in serum significantly increased from the
second lowest dose of ketamine. Insulin concentrations in plasma did not
exhibit any significant difference between groups. MCAD levels were
0.5-fold more in Group F than in Group A, while there were no
significant differences between control group and Groups B-E.
Furthermore, high concentrations (120 and 140 mg kg(-1)) of ketamine
interfered with in metabolic homoeostasis by significantly reducing LPL
activity, thus elevating triglyceride concentrations in serum without
affecting cholesterol and HDL metabolism.
Conclusions: Ketamine induces various metabolic effects due to changes
in adipose LPL activity and MCAD levels in muscles. These findings seem
to be significant only at high doses.
ER -